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UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.
Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. Rutkowski DT, et al. Among authors: kaufman rj. Dev Cell. 2008 Dec;15(6):829-40. doi: 10.1016/j.devcel.2008.10.015. Dev Cell. 2008. PMID: 19081072 Free PMC article.
Regulation of apoptosis by the unfolded protein response.
Fribley A, Zhang K, Kaufman RJ. Fribley A, et al. Among authors: kaufman rj. Methods Mol Biol. 2009;559:191-204. doi: 10.1007/978-1-60327-017-5_14. Methods Mol Biol. 2009. PMID: 19609758 Free PMC article.
Large-scale analysis of UPR-mediated apoptosis in human cells.
Fribley AM, Miller JR, Reist TE, Callaghan MU, Kaufman RJ. Fribley AM, et al. Among authors: kaufman rj. Methods Enzymol. 2011;491:57-71. doi: 10.1016/B978-0-12-385928-0.00004-3. Methods Enzymol. 2011. PMID: 21329794 Free PMC article.
Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.
Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ. Fribley AM, et al. Among authors: kaufman rj. J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893. Epub 2011 Aug 15. J Biomol Screen. 2011. PMID: 21844328 Free PMC article.
Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, Callaghan MU, Golden JE, Fribley AM, Kaufman RJ. Flaherty DP, et al. Among authors: kaufman rj. ACS Med Chem Lett. 2014 Oct 29;5(12):1278-1283. doi: 10.1021/ml5003234. eCollection 2014 Dec 11. ACS Med Chem Lett. 2014. PMID: 25530830 Free PMC article.
518 results