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Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models.
Devarajan R, Izzi V, Peltoketo H, Rask G, Kauppila S, Väisänen MR, Ruotsalainen H, Martínez-Nieto G, Karppinen SM, Väisänen T, Kaur I, Koivunen J, Sasaki T, Winqvist R, Manninen A, Wärnberg F, Sund M, Pihlajaniemi T, Heljasvaara R. Devarajan R, et al. Among authors: karppinen sm. J Clin Invest. 2023 Sep 15;133(18):e159181. doi: 10.1172/JCI159181. J Clin Invest. 2023. PMID: 37498672 Free PMC article.
Collagens XV and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumor stroma, while XVIII becomes upregulated in tumor cells and lost from microvessels.
Karppinen SM, Honkanen HK, Heljasvaara R, Riihilä P, Autio-Harmainen H, Sormunen R, Harjunen V, Väisänen MR, Väisänen T, Hurskainen T, Tasanen K, Kähäri VM, Pihlajaniemi T. Karppinen SM, et al. Exp Dermatol. 2016 May;25(5):348-54. doi: 10.1111/exd.12913. Exp Dermatol. 2016. PMID: 26660139
Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
Martínez-Nieto G, Heljasvaara R, Heikkinen A, Kaski HK, Devarajan R, Rinne O, Henriksson C, Thomson E, von Hertzen C, Miinalainen I, Ruotsalainen H, Pihlajaniemi T, Karppinen SM. Martínez-Nieto G, et al. Among authors: karppinen sm. Int J Mol Sci. 2021 Sep 15;22(18):9978. doi: 10.3390/ijms22189978. Int J Mol Sci. 2021. PMID: 34576139 Free PMC article.
Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis.
Martínez-Nieto GA, Teppo HR, Petrelius N, Izzi V, Devarajan R, Petäistö T, Liu H, Kim KS, Karppinen SM, Ruotsalainen H, Koivunen J, Mäki JM, Walker GC, Pihlajaniemi T, Gullberg D, Heljasvaara R. Martínez-Nieto GA, et al. Among authors: karppinen sm. Front Oncol. 2022 Aug 8;12:981009. doi: 10.3389/fonc.2022.981009. eCollection 2022. Front Oncol. 2022. PMID: 36003785 Free PMC article.
26 results