Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 5
2003 4
2004 5
2005 3
2006 2
2007 3
2008 6
2009 6
2010 6
2011 2
2012 5
2013 4
2014 6
2015 5
2016 1
2017 6
2018 3
2019 1
2020 3
2021 1
2022 5
2023 6
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

84 results

Results by year

Filters applied: . Clear all
Page 1
Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters.
Tollefson AE, Riemann SB, Ying B, Spencer JF, Overhulse JM, Kashemirov BA, Wold WSM, McKenna CE, Toth K. Tollefson AE, et al. Among authors: toth k. Antiviral Res. 2024 Feb;222:105799. doi: 10.1016/j.antiviral.2024.105799. Epub 2024 Jan 6. Antiviral Res. 2024. PMID: 38190973
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.
Gao S, Song L, Sylvester K, Mercorelli B, Loregian A, Toth K, Weiße RH, Useini A, Sträter N, Yang M, Ye B, Tollefson AE, Müller CE, Liu X, Zhan P. Gao S, et al. Among authors: toth k. J Med Chem. 2023 Dec 14;66(23):16426-16440. doi: 10.1021/acs.jmedchem.3c01876. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37992202
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: toth k. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Gao S, Song L, Claff T, Woodson M, Sylvester K, Jing L, Weiße RH, Cheng Y, Sträter N, Schäkel L, Gütschow M, Ye B, Yang M, Zhang T, Kang D, Toth K, Tavis J, Tollefson AE, Müller CE, Zhan P, Liu X. Gao S, et al. Among authors: toth k. J Med Chem. 2022 Dec 22;65(24):16902-16917. doi: 10.1021/acs.jmedchem.2c01716. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475694
Filociclovir is a potent inhibitor of human adenovirus F41.
Tollefson AE, Hussein ITM, Toth K, Bowlin TL. Tollefson AE, et al. Among authors: toth k. Antiviral Res. 2022 Dec;208:105431. doi: 10.1016/j.antiviral.2022.105431. Epub 2022 Oct 7. Antiviral Res. 2022. PMID: 36209985
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P. Gao S, et al. Among authors: toth k. J Med Chem. 2022 Oct 13;65(19):13343-13364. doi: 10.1021/acs.jmedchem.2c01146. Epub 2022 Sep 15. J Med Chem. 2022. PMID: 36107752
84 results