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γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Weber TA, Lundkvist J, Wanngren J, Kvartsberg H, Jin S, Larssen P, Wu D, Oliveira DV, Minta K, Brinkmalm G, Zetterberg H, Blennow K, Nordvall G, Winblad B, Portelius E, Karlström H. Weber TA, et al. Among authors: karlstrom h. J Cell Mol Med. 2022 Feb;26(3):880-892. doi: 10.1111/jcmm.17146. Epub 2021 Dec 20. J Cell Mol Med. 2022. PMID: 34931449 Free PMC article.
Notch receptor cleavage depends on but is not directly executed by presenilins.
Taniguchi Y, Karlström H, Lundkvist J, Mizutani T, Otaka A, Vestling M, Bernstein A, Donoviel D, Lendahl U, Honjo T. Taniguchi Y, et al. Among authors: karlstrom h. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4014-9. doi: 10.1073/pnas.052017699. Epub 2002 Mar 12. Proc Natl Acad Sci U S A. 2002. PMID: 11891288 Free PMC article.
Presenilin dependence of phospholipase C and protein kinase C signaling.
Dehvari N, Cedazo-Minguez A, Isacsson O, Nilsson T, Winblad B, Karlström H, Benedikz E, Cowburn RF. Dehvari N, et al. Among authors: karlstrom h. J Neurochem. 2007 Aug;102(3):848-57. doi: 10.1111/j.1471-4159.2007.04571.x. Epub 2007 Apr 16. J Neurochem. 2007. PMID: 17437536 Free article.
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H. Wanngren J, et al. Among authors: karlstrom h. J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27. J Biol Chem. 2010. PMID: 20106965 Free PMC article.
39 results