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Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP.
De Waele L, Curie A, Kangro K, Tellier E, Kaplanski G, Männik A, Tersteeg C, Joly BS, Coppo P, Veyradier A, De Meyer SF, Roose E, Vanhoorelbeke K. De Waele L, et al. Among authors: kangro k. Blood Adv. 2021 Nov 9;5(21):4480-4484. doi: 10.1182/bloodadvances.2021004971. Blood Adv. 2021. PMID: 34559219 Free PMC article.
Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura.
Velásquez Pereira LC, Roose E, Graça NAG, Sinkovits G, Kangro K, Joly BS, Tellier E, Kaplanski G, Falter T, Von Auer C, Rossmann H, Feys HB, Reti M, Prohászka Z, Lämmle B, Voorberg J, Coppo P, Veyradier A, De Meyer SF, Männik A, Vanhoorelbeke K. Velásquez Pereira LC, et al. Among authors: kangro k. J Thromb Haemost. 2021 Feb;19(2):478-488. doi: 10.1111/jth.15170. Epub 2020 Dec 31. J Thromb Haemost. 2021. PMID: 33171004 Free article.
N-glycan-mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP.
Ercig B, Graça NAG, Kangro K, Arfman T, Wichapong K, Hrdinová J, Kaijen P, van Alphen FPJ, van den Biggelaar M, Vanhoorelbeke K, Veyradier A, Coppo P, Reutelingsperger C, Nicolaes GAF, Männik A, Voorberg J. Ercig B, et al. Among authors: kangro k. Blood. 2021 May 13;137(19):2694-2698. doi: 10.1182/blood.2020007972. Blood. 2021. PMID: 33544829 Free PMC article.
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Roose E, Vidarsson G, Kangro K, Verhagen OJHM, Mancini I, Desender L, Pareyn I, Vandeputte N, Vandenbulcke A, Vendramin C, Schelpe AS, Voorberg J, Azerad MA, Gilardin L, Scully M, Dierickx D, Deckmyn H, De Meyer SF, Peyvandi F, Vanhoorelbeke K. Roose E, et al. Among authors: kangro k. Thromb Haemost. 2018 Oct;118(10):1729-1742. doi: 10.1055/s-0038-1669459. Epub 2018 Sep 20. Thromb Haemost. 2018. PMID: 30235483 Free article.
[No title available]
[No authors listed] [No authors listed] PMID: 31753929
28 results