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Activation of invasion by oncogenic reprogramming of cholesterol metabolism via increased NPC1 expression and macropinocytosis.
Skorda A, Lauridsen AR, Wu C, Huang J, Mrackova M, Winther NI, Jank V, Sztupinszki Z, Strauss R, Bilgin M, Maeda K, Liu B, Luo Y, Jäättelä M, Kallunki T. Skorda A, et al. Among authors: kallunki t. Oncogene. 2023 Aug;42(33):2495-2506. doi: 10.1038/s41388-023-02771-x. Epub 2023 Jul 7. Oncogene. 2023. PMID: 37420029 Free PMC article.
Cancer-associated lysosomal changes: friends or foes?
Kallunki T, Olsen OD, Jäättelä M. Kallunki T, et al. Oncogene. 2013 Apr 18;32(16):1995-2004. doi: 10.1038/onc.2012.292. Epub 2012 Jul 9. Oncogene. 2013. PMID: 22777359 Review.
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.
Brix DM, Tvingsholm SA, Hansen MB, Clemmensen KB, Ohman T, Siino V, Lambrughi M, Hansen K, Puustinen P, Gromova I, James P, Papaleo E, Varjosalo M, Moreira J, Jäättelä M, Kallunki T. Brix DM, et al. Among authors: kallunki t. Oncogene. 2019 Apr;38(17):3170-3184. doi: 10.1038/s41388-018-0653-x. Epub 2019 Jan 8. Oncogene. 2019. PMID: 30622337 Free PMC article.
Identification of lysosome-targeting drugs with anti-inflammatory activity as potential invasion inhibitors of treatment resistant HER2 positive cancers.
Hansen MB, Postol M, Tvingsholm S, Nielsen IØ, Dietrich TN, Puustinen P, Maeda K, Dinant C, Strauss R, Egan D, Jäättelä M, Kallunki T. Hansen MB, et al. Among authors: kallunki t. Cell Oncol (Dordr). 2021 Aug;44(4):805-820. doi: 10.1007/s13402-021-00603-2. Epub 2021 May 3. Cell Oncol (Dordr). 2021. PMID: 33939112 Free PMC article.
Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.
Lahtinen A, Lavikka K, Virtanen A, Li Y, Jamalzadeh S, Skorda A, Lauridsen AR, Zhang K, Marchi G, Isoviita VM, Ariotta V, Lehtonen O, Muranen TA, Huhtinen K, Carpén O, Hietanen S, Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S. Lahtinen A, et al. Among authors: kallunki t. Cancer Cell. 2023 Jun 12;41(6):1103-1117.e12. doi: 10.1016/j.ccell.2023.04.017. Epub 2023 May 18. Cancer Cell. 2023. PMID: 37207655 Free article.
Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.
Mathiasen DP, Egebjerg C, Andersen SH, Rafn B, Puustinen P, Khanna A, Daugaard M, Valo E, Tuomela S, Bøttzauw T, Nielsen CF, Willumsen BM, Hautaniemi S, Lahesmaa R, Westermarck J, Jäättelä M, Kallunki T. Mathiasen DP, et al. Among authors: kallunki t. Oncogene. 2012 Jan 19;31(3):390-401. doi: 10.1038/onc.2011.230. Epub 2011 Jun 27. Oncogene. 2012. PMID: 21706057
51 results