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CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process.
Altvater B, Kailayangiri S, Spurny C, Flügge M, Meltzer J, Greune L, Urban K, Schwöppe C, Brand C, Schliemann C, Hintelmann H, Harrach S, Hartmann W, Abken H, Kuehle J, Schambach A, Görlich D, Berdel WE, Rossig C. Altvater B, et al. Among authors: kailayangiri s. Cancer Gene Ther. 2023 Oct;30(10):1355-1368. doi: 10.1038/s41417-023-00642-x. Epub 2023 Jun 30. Cancer Gene Ther. 2023. PMID: 37391502 Free PMC article.
Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G.
Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, Wiendl H, Pankratz S, Meltzer J, Farwick N, Greune L, Fluegge M, Rossig C. Kailayangiri S, et al. Oncoimmunology. 2016 Oct 28;6(1):e1250050. doi: 10.1080/2162402X.2016.1250050. eCollection 2017. Oncoimmunology. 2016. PMID: 28197367 Free PMC article.
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G.
Spurny C, Kailayangiri S, Altvater B, Jamitzky S, Hartmann W, Wardelmann E, Ranft A, Dirksen U, Amler S, Hardes J, Fluegge M, Meltzer J, Farwick N, Greune L, Rossig C. Spurny C, et al. Among authors: kailayangiri s. Oncotarget. 2017 Dec 22;9(5):6536-6549. doi: 10.18632/oncotarget.23815. eCollection 2018 Jan 19. Oncotarget. 2017. PMID: 29464090 Free PMC article.
Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers.
Rossig C, Kailayangiri S, Jamitzky S, Altvater B. Rossig C, et al. Among authors: kailayangiri s. Front Oncol. 2018 Nov 12;8:513. doi: 10.3389/fonc.2018.00513. eCollection 2018. Front Oncol. 2018. PMID: 30483473 Free PMC article. Review.
EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells.
Kailayangiri S, Altvater B, Lesch S, Balbach S, Göttlich C, Kühnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Müller I, Walles H, Hartmann W, Rossig C. Kailayangiri S, et al. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. Mol Ther. 2019. PMID: 30879952 Free PMC article.
VEGFR2 as a target for CAR T cell therapy of Ewing sarcoma.
Englisch A, Altvater B, Kailayangiri S, Hartmann W, Rossig C. Englisch A, et al. Among authors: kailayangiri s. Pediatr Blood Cancer. 2020 Oct;67(10):e28313. doi: 10.1002/pbc.28313. Epub 2020 Jul 30. Pediatr Blood Cancer. 2020. PMID: 32729251
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