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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Riahi Y, Kogot-Levin A, Kadosh L, Agranovich B, Malka A, Assa M, Piran R, Avrahami D, Glaser B, Gottlieb E, Jackson F 3rd, Cerasi E, Bernal-Mizrachi E, Helman A, Leibowitz G. Riahi Y, et al. Among authors: kadosh l. Diabetologia. 2023 Oct;66(10):1925-1942. doi: 10.1007/s00125-023-05967-8. Epub 2023 Jul 22. Diabetologia. 2023. PMID: 37480416
Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition.
Kogot-Levin A, Riahi Y, Abramovich I, Mosenzon O, Agranovich B, Kadosh L, Ben-Haroush Schyr R, Kleiman D, Hinden L, Cerasi E, Ben-Zvi D, Bernal-Mizrachi E, Tam J, Gottlieb E, Leibowitz G. Kogot-Levin A, et al. Among authors: kadosh l. JCI Insight. 2023 Apr 10;8(7):e164296. doi: 10.1172/jci.insight.164296. JCI Insight. 2023. PMID: 36809274 Free PMC article.
Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.
Israeli T, Riahi Y, Garzon P, Louzada RA, Werneck-de-Castro JP, Blandino-Rosano M, Yeroslaviz-Stolper R, Kadosh L, Tornovsky-Babeay S, Hacker G, Israeli N, Agmon O, Tirosh B, Cerasi E, Bernal-Mizrachi E, Leibowitz G. Israeli T, et al. Among authors: kadosh l. Diabetes. 2022 Mar 1;71(3):453-469. doi: 10.2337/db21-0281. Diabetes. 2022. PMID: 34862201 Free PMC article.