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Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling.
Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. Winkler M, et al. Among authors: kurschner sw. J Hepatol. 2021 Feb;74(2):380-393. doi: 10.1016/j.jhep.2020.08.033. Epub 2020 Sep 9. J Hepatol. 2021. PMID: 32916216 Free article.
Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation.
Koch PS, Sandorski K, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, de la Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch FA, Heineke J, Géraud C, Goerdt S, Olsavszky V. Koch PS, et al. Among authors: kurschner sw. Front Physiol. 2021 Sep 29;12:722394. doi: 10.3389/fphys.2021.722394. eCollection 2021. Front Physiol. 2021. PMID: 34658910 Free PMC article.
ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver.
Schmid CD, Olsavszky V, Reinhart M, Weyer V, Trogisch FA, Sticht C, Winkler M, Kürschner SW, Hoffmann J, Ola R, Staniczek T, Heineke J, Straub BK, Mittler J, Schledzewski K, Ten Dijke P, Richter K, Dooley S, Géraud C, Goerdt S, Koch PS. Schmid CD, et al. Among authors: kurschner sw. Hepatology. 2023 Apr 1;77(4):1211-1227. doi: 10.1002/hep.32641. Epub 2022 Jul 17. Hepatology. 2023. PMID: 35776660 Free PMC article.
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.
Trogisch FA, Abouissa A, Keles M, Birke A, Fuhrmann M, Dittrich GM, Weinzierl N, Wink E, Cordero J, Elsherbiny A, Martin-Garrido A, Grein S, Hemanna S, Hofmann E, Nicin L, Bibli SI, Airik R, Kispert A, Kist R, Quanchao S, Kürschner SW, Winkler M, Gretz N, Mogler C, Korff T, Koch PS, Dimmeler S, Dobreva G, Heineke J. Trogisch FA, et al. Among authors: kurschner sw. Sci Transl Med. 2024 Feb 28;16(736):eabq4581. doi: 10.1126/scitranslmed.abq4581. Epub 2024 Feb 28. Sci Transl Med. 2024. PMID: 38416842