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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch M, Schraft L, Chan A, Küchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Krämer C, Clauder-Münster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Grosch M, et al. Among authors: kuchenhoff l. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. Nat Commun. 2023. PMID: 37349314 Free PMC article.
Extended methods for spatial cell classification with DBSCAN-CellX.
Küchenhoff L, Lukas P, Metz-Zumaran C, Rothhaar P, Ruggieri A, Lohmann V, Höfer T, Stanifer ML, Boulant S, Talemi SR, Graw F. Küchenhoff L, et al. Sci Rep. 2023 Nov 1;13(1):18868. doi: 10.1038/s41598-023-45190-4. Sci Rep. 2023. PMID: 37914751 Free PMC article.
Complementing Cell Taxonomies with a Multicellular Analysis of Tissues.
Ramirez Flores RO, Schäfer PSL, Küchenhoff L, Saez-Rodriguez J. Ramirez Flores RO, et al. Among authors: kuchenhoff l. Physiology (Bethesda). 2024 May 1;39(3):0. doi: 10.1152/physiol.00001.2024. Epub 2024 Feb 6. Physiology (Bethesda). 2024. PMID: 38319138 Review.
The population context is a driver of the heterogeneous response of epithelial cells to interferons.
Metz-Zumaran C, Uckeley ZM, Doldan P, Muraca F, Keser Y, Lukas P, Kuropka B, Küchenhoff L, Rastgou Talemi S, Höfer T, Freund C, Cavalcanti-Adam EA, Graw F, Stanifer M, Boulant S. Metz-Zumaran C, et al. Among authors: kuchenhoff l. Mol Syst Biol. 2024 Mar;20(3):242-275. doi: 10.1038/s44320-024-00011-2. Epub 2024 Jan 25. Mol Syst Biol. 2024. PMID: 38273161 Free PMC article.