Kästle M - Search Results

1

The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.

Kowallik S, Kritikos A, Kästle M, Thurm C, Schraven B, Simeoni L. Kowallik S, et al. Among authors: kastle m. Int J Mol Sci. 2020 Dec 24;22(1):126. doi: 10.3390/ijms22010126. Int J Mol Sci. 2020. PMID: 33374422 Free PMC article.

2

Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.

Kästle M, Merten C, Hartig R, Plaza-Sirvent C, Schmitz I, Bommhardt U, Schraven B, Simeoni L. Kästle M, et al. Int J Mol Sci. 2022 Jun 30;23(13):7271. doi: 10.3390/ijms23137271. Int J Mol Sci. 2022. PMID: 35806279 Free PMC article.

3

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ. Philipsen L, et al. Among authors: kastle m. Sci Signal. 2017 Jan 17;10(462):eaaf4736. doi: 10.1126/scisignal.aaf4736. Sci Signal. 2017. PMID: 28096507

4

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56^Lck regulates T-cell activation independently of Lck/CD45 interactions.

Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B. Kästle M, et al. Cell Commun Signal. 2020 Nov 23;18(1):183. doi: 10.1186/s12964-020-00673-z. Cell Commun Signal. 2020. PMID: 33225946 Free PMC article.

5

Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice.

Weckerle J, Mayr CH, Fundel-Clemens K, Lämmle B, Boryn L, Thomas MJ, Bretschneider T, Luippold AH, Huber HJ, Viollet C, Rist W, Veyel D, Ramirez F, Klee S, Kästle M. Weckerle J, et al. Among authors: kastle m. Am J Respir Cell Mol Biol. 2023 Oct;69(4):422-440. doi: 10.1165/rcmb.2023-0012OC. Am J Respir Cell Mol Biol. 2023. PMID: 37411041

6

Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity.

Klee S, Picart-Armada S, Wenger K, Birk G, Quast K, Veyel D, Rist W, Violet C, Luippold A, Haslinger C, Thomas M, Fernandez-Albert F, Kästle M. Klee S, et al. Among authors: kastle m. Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L245-L258. doi: 10.1152/ajplung.00253.2021. Epub 2023 Jan 10. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36625483 Free article.

7

Mapping the metabolomic and lipidomic changes in the bleomycin model of pulmonary fibrosis in young and aged mice.

Weckerle J, Picart-Armada S, Klee S, Bretschneider T, Luippold AH, Rist W, Haslinger C, Schlüter H, Thomas MJ, Krawczyk B, Fernandez-Albert F, Kästle M, Veyel D. Weckerle J, et al. Among authors: kastle m. Dis Model Mech. 2022 Jan 1;15(1):dmm049105. doi: 10.1242/dmm.049105. Epub 2022 Jan 25. Dis Model Mech. 2022. PMID: 34845494 Free PMC article.

8

RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma.

Lamb D, De Sousa D, Quast K, Fundel-Clemens K, Erjefält JS, Sandén C, Hoffmann HJ, Kästle M, Schmid R, Menden K, Delic D. Lamb D, et al. Among authors: kastle m. Respir Res. 2021 May 22;22(1):158. doi: 10.1186/s12931-021-01743-7. Respir Res. 2021. PMID: 34022896 Free PMC article.

9

Automatization and improvement of μCT analysis for murine lung disease models using a deep learning approach.

Birk G, Kästle M, Tilp C, Stierstorfer B, Klee S. Birk G, et al. Among authors: kastle m. Respir Res. 2020 May 24;21(1):124. doi: 10.1186/s12931-020-01370-8. Respir Res. 2020. PMID: 32448249 Free PMC article.

10

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target.

Kästle M, Kistler B, Lamla T, Bretschneider T, Lamb D, Nicklin P, Wyatt D. Kästle M, et al. Eur J Immunol. 2018 Nov;48(11):1904-1914. doi: 10.1002/eji.201847699. Epub 2018 Sep 14. Eur J Immunol. 2018. PMID: 30169894 Free PMC article.

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