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CIP2A inhibits PP2A in human malignancies.
Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J. Junttila MR, et al. Among authors: kahari vm. Cell. 2007 Jul 13;130(1):51-62. doi: 10.1016/j.cell.2007.04.044. Cell. 2007. PMID: 17632056 Free article.
Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
Heikkinen PT, Nummela M, Leivonen SK, Westermarck J, Hill CS, Kähäri VM, Jaakkola PM. Heikkinen PT, et al. Among authors: kahari vm. J Biol Chem. 2010 Feb 5;285(6):3740-3749. doi: 10.1074/jbc.M109.042978. Epub 2009 Dec 1. J Biol Chem. 2010. PMID: 19951945 Free PMC article.
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.
Laine A, Sihto H, Come C, Rosenfeldt MT, Zwolinska A, Niemelä M, Khanna A, Chan EK, Kähäri VM, Kellokumpu-Lehtinen PL, Sansom OJ, Evan GI, Junttila MR, Ryan KM, Marine JC, Joensuu H, Westermarck J. Laine A, et al. Among authors: kahari vm. Cancer Discov. 2013 Feb;3(2):182-97. doi: 10.1158/2159-8290.CD-12-0292. Epub 2013 Jan 10. Cancer Discov. 2013. PMID: 23306062 Free PMC article.
Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.
Mäkelä E, Pavic K, Varila T, Salmenniemi U, Löyttyniemi E, Nagelli SG, Ammunét T, Kähäri VM, Clark RE, Elo LL, Bachanaboyina VK, Lucas CM, Itälä-Remes M, Westermarck J. Mäkelä E, et al. Among authors: kahari vm. Clin Cancer Res. 2021 May 15;27(10):2848-2860. doi: 10.1158/1078-0432.CCR-20-3679. Epub 2021 Mar 5. Clin Cancer Res. 2021. PMID: 33674272
208 results