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Year Number of Results
2015 1
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2019 5
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Page 1
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Zaręba P, Łątka K, Mazur G, Gryzło B, Pasieka A, Godyń J, Panek D, Skrzypczak-Wiercioch A, Höfner GC, Latacz G, Maj M, Espargaró A, Sabaté R, Jóźwiak K, Wanner KT, Sałat K, Malawska B, Kulig K, Bajda M. Zaręba P, et al. Among authors: godyn j. Eur J Med Chem. 2023 Dec 5;261:115832. doi: 10.1016/j.ejmech.2023.115832. Epub 2023 Oct 7. Eur J Med Chem. 2023. PMID: 37837674 Free article.
Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect.
Staszewski M, Iwan M, Werner T, Bajda M, Godyń J, Latacz G, Korga-Plewko A, Kubik J, Szałaj N, Stark H, Malawska B, Więckowska A, Walczyński K. Staszewski M, et al. Among authors: godyn j. Pharmaceuticals (Basel). 2023 Apr 30;16(5):675. doi: 10.3390/ph16050675. Pharmaceuticals (Basel). 2023. PMID: 37242458 Free PMC article.
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Panek D, Pasieka A, Latacz G, Zaręba P, Szczęch M, Godyń J, Chantegreil F, Nachon F, Brazzolotto X, Skrzypczak-Wiercioch A, Walczak M, Smolik M, Sałat K, Höfner G, Wanner K, Więckowska A, Malawska B. Panek D, et al. Among authors: godyn j. Eur J Med Chem. 2023 Mar 5;249:115135. doi: 10.1016/j.ejmech.2023.115135. Epub 2023 Jan 18. Eur J Med Chem. 2023. PMID: 36696766
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Godyń J, Zaręba P, Stary D, Kaleta M, Kuder KJ, Latacz G, Mogilski S, Reiner-Link D, Frank A, Doroz-Płonka A, Olejarz-Maciej A, Sudoł-Tałaj S, Nolte T, Handzlik J, Stark H, Więckowska A, Malawska B, Kieć-Kononowicz K, Łażewska D, Bajda M. Godyń J, et al. Molecules. 2022 Dec 28;28(1):238. doi: 10.3390/molecules28010238. Molecules. 2022. PMID: 36615435 Free PMC article.
Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease.
Więckowski K, Szałaj N, Gryzło B, Wichur T, Góral I, Sługocka E, Sniecikowska J, Latacz G, Siwek A, Godyń J, Bucki A, Kołaczkowski M, Więckowska A. Więckowski K, et al. Among authors: godyn j. Int J Mol Sci. 2022 Aug 21;23(16):9443. doi: 10.3390/ijms23169443. Int J Mol Sci. 2022. PMID: 36012707 Free PMC article.
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.
Wichur T, Godyń J, Góral I, Latacz G, Bucki A, Siwek A, Głuch-Lutwin M, Mordyl B, Śniecikowska J, Walczak M, Knez D, Jukič M, Sałat K, Gobec S, Kołaczkowski M, Malawska B, Brazzolotto X, Więckowska A. Wichur T, et al. Among authors: godyn j. Eur J Med Chem. 2021 Dec 5;225:113792. doi: 10.1016/j.ejmech.2021.113792. Epub 2021 Aug 27. Eur J Med Chem. 2021. PMID: 34530376 Free article.
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
Wichur T, Pasieka A, Godyń J, Panek D, Góral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Głuch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kołaczkowski M, Sabate R, Malawska B, Więckowska A. Wichur T, et al. Among authors: godyn j. Eur J Med Chem. 2021 Dec 5;225:113783. doi: 10.1016/j.ejmech.2021.113783. Epub 2021 Aug 19. Eur J Med Chem. 2021. PMID: 34461507 Free article.
34 results