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Page 1
Showing results for fus tls
Search for Just LS instead (1 results)
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr. Kwiatkowski TJ Jr, et al. Science. 2009 Feb 27;323(5918):1205-8. doi: 10.1126/science.1166066. Science. 2009. PMID: 19251627
We report here 13 mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specific for familial ALS. The FUS/TLS protein binds to RNA, functions in diverse processes, and is normally located predominantly i …
We report here 13 mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specif …
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H. Xue YC, et al. J Virol. 2021 May 24;95(12):e00304-21. doi: 10.1128/JVI.00304-21. Print 2021 May 24. J Virol. 2021. PMID: 33827951 Free PMC article.
In this study, we explored the interplay between the host RNA-binding protein FUS/TLS and CVB3 and found that FUS/TLS restricts CVB3 replication through direct inhibition of viral RNA transcription/translation and through regulation of cellular antivir …
In this study, we explored the interplay between the host RNA-binding protein FUS/TLS and CVB3 and found that FUS/TL …
TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review.
Zhang H, Zhan Q, Wang X, Gao F, Yu J, Wang J, Fu W, Wang P, Wei X, Zhang L. Zhang H, et al. Ann Hematol. 2022 Dec;101(12):2583-2600. doi: 10.1007/s00277-022-04979-5. Epub 2022 Oct 1. Ann Hematol. 2022. PMID: 36181538 Free PMC article. Review.
Among the patients in our hospital, five cases were diagnosed as acute leukemia, and one was myelodysplastic syndrome evolved to acute myeloid leukemia, harboring TLS/FUS-ERG fusion gene; all the cases were detected t(16;21)(p11;q22) translocation, and five cases sh …
Among the patients in our hospital, five cases were diagnosed as acute leukemia, and one was myelodysplastic syndrome evolved to acute myelo …
Functions of FUS/TLS from DNA repair to stress response: implications for ALS.
Sama RR, Ward CL, Bosco DA. Sama RR, et al. ASN Neuro. 2014 Jun 1;6(4):1759091414544472. doi: 10.1177/1759091414544472. ASN Neuro. 2014. PMID: 25289647 Free PMC article. Review.
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. FUS was initially …
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is inv …
TLS/FUS: a protein in cancer and ALS.
Tan AY, Manley JL. Tan AY, et al. Cell Cycle. 2012 Sep 15;11(18):3349-50. doi: 10.4161/cc.21875. Epub 2012 Aug 23. Cell Cycle. 2012. PMID: 22918236 Free PMC article.
Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins.
Ratti A, Buratti E. Ratti A, et al. J Neurochem. 2016 Aug;138 Suppl 1:95-111. doi: 10.1111/jnc.13625. Epub 2016 Jun 15. J Neurochem. 2016. PMID: 27015757 Free article. Review.
This aim, however, must be preceded by an accurate evaluation of TDP-43 and FUS/TLS biological functions, both in physiological and disease conditions. ...The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS proteins and t …
This aim, however, must be preceded by an accurate evaluation of TDP-43 and FUS/TLS biological functions, both in physiologica …
TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration.
Fiesel FC, Kahle PJ. Fiesel FC, et al. FEBS J. 2011 Oct;278(19):3550-68. doi: 10.1111/j.1742-4658.2011.08258.x. Epub 2011 Aug 24. FEBS J. 2011. PMID: 21777389 Free article. Review.
Moreover, the genes encoding TDP-43 and FUS are linked to these diseases. Both TDP-43 and FUS contain RNA binding motifs, and specific targets are being identified. Potential actions of TDP-43 and FUS include transcriptional regulation, mRNA processing and mi …
Moreover, the genes encoding TDP-43 and FUS are linked to these diseases. Both TDP-43 and FUS contain RNA binding motifs, and …
Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD).
Lourenco GF, Janitz M, Huang Y, Halliday GM. Lourenco GF, et al. Neurobiol Dis. 2015 Oct;82:445-454. doi: 10.1016/j.nbd.2015.07.011. Epub 2015 Jul 26. Neurobiol Dis. 2015. PMID: 26220395 Review.
Recent studies report that FTLD/ALS-related proteins TDP-43 and FUS/TLS bind lncRNAs, and that several lncRNAs have binding sites for TDP-43 and/or FUS/TLS. These findings raise important questions about how TDP-43 and FUS/TLS pathologies …
Recent studies report that FTLD/ALS-related proteins TDP-43 and FUS/TLS bind lncRNAs, and that several lncRNAs have binding si …
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.
Da Cruz S, Cleveland DW. Da Cruz S, et al. Curr Opin Neurobiol. 2011 Dec;21(6):904-19. doi: 10.1016/j.conb.2011.05.029. Epub 2011 Aug 2. Curr Opin Neurobiol. 2011. PMID: 21813273 Free PMC article. Review.
Dominant mutations in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of inherited Amyotrophic Lateral Sclerosis (ALS). TDP-43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA processing as c …
Dominant mutations in two DNA/RNA binding proteins, TDP-43 and FUS/TLS, are causes of inherited Amyotrophic Lateral Sclerosis …
[FUS/TLS as a polyglutamine aggregate interacting protein].
Nukina N. Nukina N. Rinsho Shinkeigaku. 2010 Nov;50(11):945-7. doi: 10.5692/clinicalneurol.50.945. Rinsho Shinkeigaku. 2010. PMID: 21921521 Review. Japanese.
In vitro study revealed that TLS could directly bind to truncated N-terminal huntingtin (tNhtt) aggregates but could not bind to monomer, indicating that the tNhtt protein acquired the ability to sequester TLS after forming aggregates. ...After this report, FUS …
In vitro study revealed that TLS could directly bind to truncated N-terminal huntingtin (tNhtt) aggregates but could not bind to mono …
416 results