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Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen.
Yang Y, Beigneux AP, Song W, Nguyen LP, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim JR, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, Young SG. Yang Y, et al. Among authors: jung h. J Clin Invest. 2023 Dec 1;133(23):e172600. doi: 10.1172/JCI172600. J Clin Invest. 2023. PMID: 37824203 Free PMC article.
Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.
Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: jung h, jung cj. J Clin Invest. 2022 Mar 1;132(5):e157500. doi: 10.1172/JCI157500. J Clin Invest. 2022. PMID: 35229724 Free PMC article.
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.
Song W, Yang Y, Heizer P, Tu Y, Weston TA, Kim JR, Munguia P, Jung H, Fong JL, Tran C, Ploug M, Beigneux AP, Young SG, Fong LG. Song W, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2219833120. doi: 10.1073/pnas.2219833120. Epub 2023 Feb 14. Proc Natl Acad Sci U S A. 2023. PMID: 36787365 Free PMC article.
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.
Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2313825120. doi: 10.1073/pnas.2313825120. Epub 2023 Oct 23. Proc Natl Acad Sci U S A. 2023. PMID: 37871217 Free PMC article.
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.
Chen YQ, Yang Y, Zhen EY, Beyer TP, Li H, Wen Y, Ehsani M, Jackson N, Xie K, Jung H, Scheithauer JL, Kumari A, Birrane G, Russell AM, Balasubramaniam D, Liao Z, Siegel RW, Qian Y, Ploug M, Young SG, Konrad RJ. Chen YQ, et al. Among authors: jung h. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2322332121. doi: 10.1073/pnas.2322332121. Epub 2024 Apr 16. Proc Natl Acad Sci U S A. 2024. PMID: 38625948
Histopathologic image-based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer.
Ahn B, Moon D, Kim HS, Lee C, Cho NH, Choi HK, Kim D, Lee JY, Nam EJ, Won D, An HJ, Kwon SY, Shin SJ, Jung HR, Kwon D, Park H, Kim M, Cha YJ, Park H, Lee Y, Noh S, Lee YM, Choi SE, Kim JM, Sung SH, Park E. Ahn B, et al. Among authors: jung hr. Nat Commun. 2024 May 18;15(1):4253. doi: 10.1038/s41467-024-48667-6. Nat Commun. 2024. PMID: 38762636 Free PMC article.
Integrated proteomic and genomic analysis to identify predictive biomarkers for valproate response in bipolar disorder: a 6-month follow-up study.
Lee H, Han D, Hong KS, Ha K, Kim H, Cho EY, Myung W, Rhee SJ, Kim J, Ha TH, Lee KE, Jung HW, Lee Y, Lee D, Yu H, Lee D, Park YS, Ahn YM, Baek JH, Kim SH. Lee H, et al. Among authors: jung hw. Int J Bipolar Disord. 2024 May 17;12(1):19. doi: 10.1186/s40345-024-00342-x. Int J Bipolar Disord. 2024. PMID: 38758284 Free PMC article.
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