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A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.
Int J Biochem Cell Biol. 2012 Dec;44(12):2204-11. doi: 10.1016/j.biocel.2012.09.004. Epub 2012 Sep 12.
Int J Biochem Cell Biol. 2012.
PMID: 22982239
Free PMC article.
Inhibition of the unfolded protein response by ricin a-chain enhances its cytotoxicity in mammalian cells.
Wang CT, Jetzt AE, Cheng JS, Cohick WS.
Wang CT, et al. Among authors: cheng js.
Toxins (Basel). 2011 May;3(5):453-68. doi: 10.3390/toxins3050453. Epub 2011 May 10.
Toxins (Basel). 2011.
PMID: 22069719
Free PMC article.
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Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells.
Jetzt AE, Cheng JS, Tumer NE, Cohick WS.
Jetzt AE, et al. Among authors: cheng js.
Int J Biochem Cell Biol. 2009 Dec;41(12):2503-10. doi: 10.1016/j.biocel.2009.08.007. Epub 2009 Aug 18.
Int J Biochem Cell Biol. 2009.
PMID: 19695342
Free PMC article.
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