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Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems.
Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K. Nepovimova E, et al. Among authors: jost p. Bioorg Chem. 2021 Feb;107:104596. doi: 10.1016/j.bioorg.2020.104596. Epub 2020 Dec 28. Bioorg Chem. 2021. PMID: 33421953
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K. Nepovimova E, et al. Among authors: jost p. J Med Chem. 2015 Nov 25;58(22):8985-9003. doi: 10.1021/acs.jmedchem.5b01325. Epub 2015 Nov 10. J Med Chem. 2015. PMID: 26503905
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E, Fedunova D, Horak M, Kaniakova M, Wang ZJ, Hamouda AK, Kuca K. Gazova Z, et al. Among authors: jost p. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):607-619. doi: 10.1016/j.bbadis.2016.11.020. Epub 2016 Nov 16. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27865910 Free article.
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K. Mezeiova E, et al. Among authors: jost p. Molecules. 2017 Jul 28;22(8):1265. doi: 10.3390/molecules22081265. Molecules. 2017. PMID: 28788095 Free PMC article.
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. Soukup O, et al. Among authors: jost p. Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657. Med Chem. 2018. PMID: 29332594
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O. Hepnarova V, et al. Among authors: jost p. Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083. Epub 2018 Mar 2. Eur J Med Chem. 2018. PMID: 29533874
228 results