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2-Oxo-3-alkynoic acids, universal mechanism-based inactivators of thiamin diphosphate-dependent decarboxylases: synthesis and evidence for potent inactivation of the pyruvate dehydrogenase multienzyme complex.
Brown A, Nemeria N, Yi J, Zhang D, Jordan WB, Machado RS, Guest JR, Jordan F. Brown A, et al. Among authors: jordan wb, jordan f. Biochemistry. 1997 Jul 1;36(26):8071-81. doi: 10.1021/bi970094y. Biochemistry. 1997. PMID: 9201955
A new class of compounds, the 2-oxo-3-alkynoic acids with a phenyl substituent at carbon 4 was reported by the authors as potent irreversible and mechanism-based inhibitors of the thiamin diphosphate- (ThDP-) dependent enzyme pyruvate decarboxylase [Chiu, C.-F., & J …
A new class of compounds, the 2-oxo-3-alkynoic acids with a phenyl substituent at carbon 4 was reported by the authors as potent irreversibl …
Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition.
Nemeria N, Yan Y, Zhang Z, Brown AM, Arjunan P, Furey W, Guest JR, Jordan F. Nemeria N, et al. Among authors: jordan f. J Biol Chem. 2001 Dec 7;276(49):45969-78. doi: 10.1074/jbc.M104116200. Epub 2001 Oct 2. J Biol Chem. 2001. PMID: 11583990 Free article.
Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase.
Nemeria N, Arjunan P, Brunskill A, Sheibani F, Wei W, Yan Y, Zhang S, Jordan F, Furey W. Nemeria N, et al. Among authors: jordan f. Biochemistry. 2002 Dec 31;41(52):15459-67. doi: 10.1021/bi0205909. Biochemistry. 2002. PMID: 12501174
Expression and purification of the dihydrolipoamide acetyltransferase and dihydrolipoamide dehydrogenase subunits of the Escherichia coli pyruvate dehydrogenase multienzyme complex: a mass spectrometric assay for reductive acetylation of dihydrolipoamide acetyltransferase.
Wei W, Li H, Nemeria N, Jordan F. Wei W, et al. Among authors: jordan f. Protein Expr Purif. 2003 Mar;28(1):140-50. doi: 10.1016/s1046-5928(02)00674-5. Protein Expr Purif. 2003. PMID: 12651118
Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role.
Jordan F, Nemeria NS, Zhang S, Yan Y, Arjunan P, Furey W. Jordan F, et al. J Am Chem Soc. 2003 Oct 22;125(42):12732-8. doi: 10.1021/ja0346126. J Am Chem Soc. 2003. PMID: 14558820
It was recently reported (Jordan, F.; Zhang, Z.; Sergienko, E. A. Bioorg. Chem. 2002, 30, 188-198) that addition to the E477Q active-center variant of yeast pyruvate decarboxylase of (a) pyruvate on a rapid-scan UV stopped-flow, or (b) acetaldehyde or benzoylformate …
It was recently reported (Jordan, F.; Zhang, Z.; Sergienko, E. A. Bioorg. Chem. 2002, 30, 188-198) that addition to the E477Q …
Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.
Nemeria N, Baykal A, Joseph E, Zhang S, Yan Y, Furey W, Jordan F. Nemeria N, et al. Among authors: jordan f. Biochemistry. 2004 Jun 1;43(21):6565-75. doi: 10.1021/bi049549r. Biochemistry. 2004. PMID: 15157089
Addition of the tetrahedral ThDP-acetaldehyde adduct, 2-alpha-hydroxyethylThDP, to PDHc-E1 generates the positive band at 300 nm, consistent with the formation of the 1',4'-iminopyrimidine tautomer, as also demonstrated for phosphonolactylthiamin diphosphate, a stable analogue of …
Addition of the tetrahedral ThDP-acetaldehyde adduct, 2-alpha-hydroxyethylThDP, to PDHc-E1 generates the positive band at 300 nm, consistent …
564 results