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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG. Cheng SC, et al. Among authors: joosten la. Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684. Science. 2014. PMID: 25258083 Free PMC article.
The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.
Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, Barrera P, Joosten LA, van Riel PL, van den Berg WB. Radstake TR, et al. Among authors: joosten la. Arthritis Rheum. 2004 Mar;50(3):999-1001. doi: 10.1002/art.20114. Arthritis Rheum. 2004. PMID: 15022344 Free article. No abstract available.
Toll-like receptor 2 controls expansion and function of regulatory T cells.
Sutmuller RP, den Brok MH, Kramer M, Bennink EJ, Toonen LW, Kullberg BJ, Joosten LA, Akira S, Netea MG, Adema GJ. Sutmuller RP, et al. Among authors: joosten la. J Clin Invest. 2006 Feb;116(2):485-94. doi: 10.1172/JCI25439. Epub 2006 Jan 19. J Clin Invest. 2006. PMID: 16424940 Free PMC article.
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, Barrera P, van de Loo FA, Dinarello CA, van den Berg WB. Joosten LA, et al. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3298-303. doi: 10.1073/pnas.0511233103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492735 Free PMC article.
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW. Netea MG, et al. Among authors: joosten la. Nat Med. 2006 Jun;12(6):650-6. doi: 10.1038/nm1415. Epub 2006 May 28. Nat Med. 2006. PMID: 16732281
Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4.
Popa C, Abdollahi-Roodsaz S, Joosten LA, Takahashi N, Sprong T, Matera G, Liberto MC, Foca A, van Deuren M, Kullberg BJ, van den Berg WB, van der Meer JW, Netea MG. Popa C, et al. Among authors: joosten la. Infect Immun. 2007 Oct;75(10):4831-7. doi: 10.1128/IAI.00237-07. Epub 2007 Jul 2. Infect Immun. 2007. PMID: 17606598 Free PMC article.
763 results