Jones HBL - Search Results

1

Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.

Imhoff RD, Patel R, Safdar MH, Jones HBL, Pinto-Fernandez A, Vendrell I, Chen H, Muli CS, Krabill AD, Kessler BM, Wendt MK, Das C, Flaherty DP. Imhoff RD, et al. Among authors: jones hbl. J Med Chem. 2024 Mar 28;67(6):4496-4524. doi: 10.1021/acs.jmedchem.3c01661. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488146

2

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.

Jones HBL, Heilig R, Fischer R, Kessler BM, Pinto-Fernández A. Jones HBL, et al. Front Chem. 2021 Feb 25;9:640105. doi: 10.3389/fchem.2021.640105. eCollection 2021. Front Chem. 2021. PMID: 33718328 Free PMC article.

3

ABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods.

Jones HBL, Heilig R, Davis S, Fischer R, Kessler BM, Pinto-Fernández A. Jones HBL, et al. Int J Mol Sci. 2022 Mar 17;23(6):3263. doi: 10.3390/ijms23063263. Int J Mol Sci. 2022. PMID: 35328685 Free PMC article.

4

Activity-Based Protein Profiling (ABPP) for Cellular Deubiquitinase (DUB) and Inhibitor Profiling at Deep and High-Throughput Levels.

Jones HBL, Heilig R, Kessler BM, Pinto-Fernández A. Jones HBL, et al. Methods Mol Biol. 2023;2591:101-122. doi: 10.1007/978-1-0716-2803-4_7. Methods Mol Biol. 2023. PMID: 36350545

5

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.

O'Brien DP, Jones HBL, Guenther F, Murphy EJ, England KS, Vendrell I, Anderson M, Brennan PE, Davis JB, Pinto-Fernández A, Turnbull AP, Kessler BM. O'Brien DP, et al. Among authors: jones hbl. Mol Cell Proteomics. 2023 Aug;22(8):100609. doi: 10.1016/j.mcpro.2023.100609. Epub 2023 Jun 28. Mol Cell Proteomics. 2023. PMID: 37385347 Free PMC article.

6

Deubiquitinases in muscle physiology and disorders.

Olie CS, O'Brien DP, Jones HBL, Liang Z, Damianou A, Sur-Erdem I, Pinto-Fernández A, Raz V, Kessler BM. Olie CS, et al. Among authors: jones hbl. Biochem Soc Trans. 2024 May 8:BST20230562. doi: 10.1042/BST20230562. Online ahead of print. Biochem Soc Trans. 2024. PMID: 38716888

7

Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover.

Winter SD, Jones HBL, Răsădean DM, Crean RM, Danson MJ, Pantoş GD, Katona G, Prentice E, Arcus VL, van der Kamp MW, Pudney CR. Winter SD, et al. Among authors: jones hbl. ACS Catal. 2021 Dec 17;11(24):14854-14863. doi: 10.1021/acscatal.1c04679. Epub 2021 Nov 29. ACS Catal. 2021. PMID: 34956689 Free PMC article.

8

Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes.

Subramanian S, Jones HBL, Frustaci S, Winter S, van der Kamp MW, Arcus VL, Pudney CR, Vollmer F. Subramanian S, et al. Among authors: jones hbl. ACS Appl Nano Mater. 2021 May 28;4(5):4576-4583. doi: 10.1021/acsanm.1c00176. Epub 2021 Mar 29. ACS Appl Nano Mater. 2021. PMID: 34085031 Free PMC article.

9

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift.

Knight MJ, Woolley RE, Kwok A, Parsons S, Jones HBL, Gulácsy CE, Phaal P, Kassaar O, Dawkins K, Rodriguez E, Marques A, Bowsher L, Wells SA, Watts A, van den Elsen JMH, Turner A, O'Hara J, Pudney CR. Knight MJ, et al. Among authors: jones hbl. Biochem J. 2020 Sep 30;477(18):3599-3612. doi: 10.1042/BCJ20200580. Biochem J. 2020. PMID: 32869839 Free PMC article.

10

Exposing the Interplay Between Enzyme Turnover, Protein Dynamics, and the Membrane Environment in Monoamine Oxidase B.

Jones HBL, Crean RM, Mullen A, Kendrick EG, Bull SD, Wells SA, Carbery DR, MacMillan F, van der Kamp MW, Pudney CR. Jones HBL, et al. Biochemistry. 2019 May 7;58(18):2362-2372. doi: 10.1021/acs.biochem.9b00213. Epub 2019 Apr 23. Biochemistry. 2019. PMID: 30964996

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