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Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake.
Cegla J, Troke RC, Jones B, Tharakan G, Kenkre J, McCullough KA, Lim CT, Parvizi N, Hussein M, Chambers ES, Minnion J, Cuenco J, Ghatei MA, Meeran K, Tan TM, Bloom SR. Cegla J, et al. Among authors: jones b. Diabetes. 2014 Nov;63(11):3711-20. doi: 10.2337/db14-0242. Epub 2014 Jun 17. Diabetes. 2014. PMID: 24939425 Clinical Trial.
Optical Control of Insulin Secretion Using an Incretin Switch.
Broichhagen J, Podewin T, Meyer-Berg H, von Ohlen Y, Johnston NR, Jones BJ, Bloom SR, Rutter GA, Hoffmann-Röder A, Hodson DJ, Trauner D. Broichhagen J, et al. Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15565-9. doi: 10.1002/anie.201506384. Epub 2015 Nov 2. Angew Chem Int Ed Engl. 2015. PMID: 26585495 Free PMC article.
Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.
Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJ. Broichhagen J, et al. Angew Chem Int Ed Engl. 2016 May 4;55(19):5865-8. doi: 10.1002/anie.201600957. Epub 2016 Apr 5. Angew Chem Int Ed Engl. 2016. PMID: 27059784 Free PMC article.
A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.
Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A. Buenaventura T, et al. Among authors: jones b. Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28. Diabetes. 2018. PMID: 29284659 Free article.
Control of insulin secretion by GLP-1.
Jones B, Bloom SR, Buenaventura T, Tomas A, Rutter GA. Jones B, et al. Peptides. 2018 Feb;100:75-84. doi: 10.1016/j.peptides.2017.12.013. Peptides. 2018. PMID: 29412835 Free article. Review.
Targeting GLP-1 receptor trafficking to improve agonist efficacy.
Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR. Jones B, et al. Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2. Nat Commun. 2018. PMID: 29686402 Free PMC article.
Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.
Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua AI, Norman H, McGlone ER, Klymchenko AS, Corrêa IR Jr, Walker A, Inoue A, Hanyaloglu A, Grimes J, Koszegi Z, Calebiro D, Rutter GA, Bloom SR, Jones B, Tomas A. Buenaventura T, et al. Among authors: jones b. PLoS Biol. 2019 Aug 20;17(8):e3000097. doi: 10.1371/journal.pbio.3000097. eCollection 2019 Aug. PLoS Biol. 2019. PMID: 31430273 Free PMC article.
New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling.
Tomas A, Jones B, Leech C. Tomas A, et al. Among authors: jones b. J Mol Biol. 2020 Mar 6;432(5):1347-1366. doi: 10.1016/j.jmb.2019.08.009. Epub 2019 Aug 22. J Mol Biol. 2020. PMID: 31446075 Free article. Review.
7,114 results