Johnson JW - Search Results

1

A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor.

French S, Guo ABY, Ellis MJ, Deisinger JP, Johnson JW, Rachwalski K, Piquette ZA, Lluka T, Zary M, Gamage S, Magolan J, Brown ED. French S, et al. Among authors: johnson jw. Cell Rep. 2024 Apr 23;43(4):114053. doi: 10.1016/j.celrep.2024.114053. Epub 2024 Apr 4. Cell Rep. 2024. PMID: 38578824 Free article.

2

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.

Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK, Brown ED. Ellis MJ, et al. Among authors: johnson jw. Nat Commun. 2019 Jan 14;10(1):197. doi: 10.1038/s41467-018-08190-x. Nat Commun. 2019. PMID: 30643129 Free PMC article.

3

Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery.

Johnson JW, Ellis MJ, Piquette ZA, MacNair C, Carfrae L, Bhando T, Ritchie NE, Saliba P, Brown ED, Magolan J. Johnson JW, et al. ACS Med Chem Lett. 2022 Jan 21;13(2):284-291. doi: 10.1021/acsmedchemlett.1c00648. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35178184 Free PMC article.

4

Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane.

Klobucar K, Côté JP, French S, Borrillo L, Guo ABY, Serrano-Wu MH, Lee KK, Hubbard B, Johnson JW, Gaulin JL, Magolan J, Hung DT, Brown ED. Klobucar K, et al. Among authors: johnson jw. ACS Chem Biol. 2021 May 21;16(5):929-942. doi: 10.1021/acschembio.1c00179. Epub 2021 May 11. ACS Chem Biol. 2021. PMID: 33974796

5

Hexafluoroisopropyl Sulfamate: A Useful Reagent for the Synthesis of Sulfamates and Sulfamides.

Sguazzin MA, Johnson JW, Magolan J. Sguazzin MA, et al. Among authors: johnson jw. Org Lett. 2021 May 7;23(9):3373-3378. doi: 10.1021/acs.orglett.1c00855. Epub 2021 Apr 16. Org Lett. 2021. PMID: 33861615

6

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.

Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED. Klobucar K, et al. Among authors: johnson jw. ACS Infect Dis. 2022 Oct 14;8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. Epub 2022 Sep 13. ACS Infect Dis. 2022. PMID: 36098580

7

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

Puumala E, Sychantha D, Lach E, Reeves S, Nabeela S, Fogal M, Nigam A, Johnson JW, Aspuru-Guzik A, Shapiro RS, Uppuluri P, Kalyaanamoorthy S, Magolan J, Whitesell L, Robbins N, Wright GD, Cowen LE. Puumala E, et al. Among authors: johnson jw. Cell Chem Biol. 2024 Apr 18;31(4):760-775.e17. doi: 10.1016/j.chembiol.2024.01.010. Epub 2024 Feb 22. Cell Chem Biol. 2024. PMID: 38402621 Free article.

8

A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity.

Alder A, Struck NS, Xu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD. Alder A, et al. Among authors: johnson jw. Cell Chem Biol. 2022 May 19;29(5):840-853.e6. doi: 10.1016/j.chembiol.2021.10.005. Epub 2021 Oct 27. Cell Chem Biol. 2022. PMID: 34710358 Free article.

9

Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory.

Cook MA, Pallant D, Ejim L, Sutherland AD, Wang X, Johnson JW, McCusker S, Chen X, George M, Chou S, Koteva K, Wang W, Hobson C, Hackenberger D, Waglechner N, Ejim O, Campbell T, Medina R, MacNeil LT, Wright GD. Cook MA, et al. Among authors: johnson jw. J Ind Microbiol Biotechnol. 2023 Feb 17;50(1):kuad042. doi: 10.1093/jimb/kuad042. J Ind Microbiol Biotechnol. 2023. PMID: 38052426 Free PMC article.

10

Evolving medicinal chemistry strategies in antibiotic discovery.

Pawlowski AC, Johnson JW, Wright GD. Pawlowski AC, et al. Among authors: johnson jw. Curr Opin Biotechnol. 2016 Dec;42:108-117. doi: 10.1016/j.copbio.2016.04.006. Epub 2016 Apr 24. Curr Opin Biotechnol. 2016. PMID: 27116217 Review.

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