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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. Hur JY, et al. Among authors: johnson ds. Nature. 2020 Oct;586(7831):735-740. doi: 10.1038/s41586-020-2681-2. Epub 2020 Sep 2. Nature. 2020. PMID: 32879487 Free PMC article.
Development of clickable active site-directed photoaffinity probes for γ-secretase.
Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Crump CJ, et al. Among authors: johnson ds. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20. Bioorg Med Chem Lett. 2012. PMID: 22418280 Free PMC article.
BMS-708,163 targets presenilin and lacks notch-sparing activity.
Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. Crump CJ, et al. Among authors: johnson ds. Biochemistry. 2012 Sep 18;51(37):7209-11. doi: 10.1021/bi301137h. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22931393 Free PMC article.
Structural and Chemical Biology of Presenilin Complexes.
Johnson DS, Li YM, Pettersson M, St George-Hyslop PH. Johnson DS, et al. Cold Spring Harb Perspect Med. 2017 Dec 1;7(12):a024067. doi: 10.1101/cshperspect.a024067. Cold Spring Harb Perspect Med. 2017. PMID: 28320827 Free PMC article. Review.
Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes.
Gertsik N, Am Ende CW, Geoghegan KF, Nguyen C, Mukherjee P, Mente S, Seneviratne U, Johnson DS, Li YM. Gertsik N, et al. Among authors: johnson ds. Cell Chem Biol. 2017 Jan 19;24(1):3-8. doi: 10.1016/j.chembiol.2016.12.006. Epub 2017 Jan 5. Cell Chem Biol. 2017. PMID: 28065657 Free PMC article.
333 results