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Year Number of Results
2002 2
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2004 6
2005 8
2006 8
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2009 4
2010 1
2011 7
2012 6
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2014 5
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66 results

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Page 1
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
Sonousi A, Quirke JCK, Waduge P, Janusic T, Gysin M, Haldimann K, Xu S, Hobbie SN, Sha SH, Schacht J, Chow CS, Vasella A, Böttger EC, Crich D. Sonousi A, et al. Among authors: schacht j. ChemMedChem. 2021 Jan 19;16(2):335-339. doi: 10.1002/cmdc.202000726. Epub 2020 Oct 23. ChemMedChem. 2021. PMID: 33007139 Free PMC article.
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
Quirke JCK, Rajasekaran P, Sarpe VA, Sonousi A, Osinnii I, Gysin M, Haldimann K, Fang QJ, Shcherbakov D, Hobbie SN, Sha SH, Schacht J, Vasella A, Böttger EC, Crich D. Quirke JCK, et al. Among authors: schacht j. J Am Chem Soc. 2020 Jan 8;142(1):530-544. doi: 10.1021/jacs.9b11601. Epub 2019 Dec 17. J Am Chem Soc. 2020. PMID: 31790244 Free PMC article.
Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
Matsushita T, Sati GC, Kondasinghe N, Pirrone MG, Kato T, Waduge P, Kumar HS, Sanchon AC, Dobosz-Bartoszek M, Shcherbakov D, Juhas M, Hobbie SN, Schrepfer T, Chow CS, Polikanov YS, Schacht J, Vasella A, Böttger EC, Crich D. Matsushita T, et al. Among authors: schacht j. J Am Chem Soc. 2019 Mar 27;141(12):5051-5061. doi: 10.1021/jacs.9b01693. Epub 2019 Mar 13. J Am Chem Soc. 2019. PMID: 30793894 Free PMC article.
Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.
Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC. Akbergenov R, et al. Among authors: schacht j. EMBO Rep. 2018 Nov;19(11):e46193. doi: 10.15252/embr.201846193. Epub 2018 Sep 20. EMBO Rep. 2018. PMID: 30237157 Free PMC article.
Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.
Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D. Sonousi A, et al. Among authors: schacht j. ACS Infect Dis. 2018 Jul 13;4(7):1114-1120. doi: 10.1021/acsinfecdis.8b00052. Epub 2018 May 10. ACS Infect Dis. 2018. PMID: 29708331 Free PMC article.
66 results