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γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Weber TA, Lundkvist J, Wanngren J, Kvartsberg H, Jin S, Larssen P, Wu D, Oliveira DV, Minta K, Brinkmalm G, Zetterberg H, Blennow K, Nordvall G, Winblad B, Portelius E, Karlström H. Weber TA, et al. Among authors: jin s. J Cell Mol Med. 2022 Feb;26(3):880-892. doi: 10.1111/jcmm.17146. Epub 2021 Dec 20. J Cell Mol Med. 2022. PMID: 34931449 Free PMC article.
Evidence for dimeric BACE-mediated APP processing.
Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U. Jin S, et al. Biochem Biophys Res Commun. 2010 Feb 26;393(1):21-7. doi: 10.1016/j.bbrc.2010.01.064. Epub 2010 Jan 25. Biochem Biophys Res Commun. 2010. PMID: 20097169
Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.
Borgegård T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, Wollberg P, Stockling K, Karlström H, Malmberg A, Lund J, Arvidsson PI, De Strooper B, Lendahl U, Lundkvist J. Borgegård T, et al. Among authors: jin s. J Neurosci. 2012 Nov 28;32(48):17297-305. doi: 10.1523/JNEUROSCI.1451-12.2012. J Neurosci. 2012. PMID: 23197721 Free PMC article.
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.
Oliveira DV, Coupland KG, Shao W, Jin S, Del Gaudio F, Wang S, Fox R, Rutten JW, Sandin J, Zetterberg H, Lundkvist J, Lesnik Oberstein SA, Lendahl U, Karlström H. Oliveira DV, et al. Among authors: jin s. EMBO Mol Med. 2023 Feb 8;15(2):e16556. doi: 10.15252/emmm.202216556. Epub 2022 Dec 16. EMBO Mol Med. 2023. PMID: 36524456 Free PMC article.
9,403 results