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Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance.
Zhu Y, Lu J, Han ML, Jiang X, Azad MAK, Patil NA, Lin YW, Zhao J, Hu Y, Yu HH, Chen K, Boyce JD, Dunstan RA, Lithgow T, Barlow CK, Li W, Schneider-Futschik EK, Wang J, Gong B, Sommer B, Creek DJ, Fu J, Wang L, Schreiber F, Velkov T, Li J. Zhu Y, et al. Among authors: jiang x. Adv Sci (Weinh). 2020 Jun 8;7(15):2000704. doi: 10.1002/advs.202000704. eCollection 2020 Aug. Adv Sci (Weinh). 2020. PMID: 32775156 Free PMC article.
Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii.
Jiang X, Yang K, Yuan B, Han M, Zhu Y, Roberts KD, Patil NA, Li J, Gong B, Hancock REW, Velkov T, Schreiber F, Wang L, Li J. Jiang X, et al. J Antimicrob Chemother. 2020 Dec 1;75(12):3534-3543. doi: 10.1093/jac/dkaa376. J Antimicrob Chemother. 2020. PMID: 32911540 Free PMC article.
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii.
Jiang X, Patil NA, Azad MAK, Wickremasinghe H, Yu H, Zhao J, Zhang X, Li M, Gong B, Wan L, Ma W, Thompson PE, Yang K, Yuan B, Schreiber F, Wang L, Velkov T, Roberts KD, Li J. Jiang X, et al. Chem Sci. 2021 Aug 19;12(36):12211-12220. doi: 10.1039/d1sc03460j. eCollection 2021 Sep 22. Chem Sci. 2021. PMID: 34667587 Free PMC article.
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
Roberts KD, Zhu Y, Azad MAK, Han ML, Wang J, Wang L, Yu HH, Horne AS, Pinson JA, Rudd D, Voelcker NH, Patil NA, Zhao J, Jiang X, Lu J, Chen K, Lomovskaya O, Hecker SJ, Thompson PE, Nation RL, Dudley MN, Griffith DC, Velkov T, Li J. Roberts KD, et al. Among authors: jiang x. Nat Commun. 2022 Mar 25;13(1):1625. doi: 10.1038/s41467-022-29234-3. Nat Commun. 2022. PMID: 35338128 Free PMC article.
Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity.
Lu J, Azad MAK, Moreau JLM, Zhu Y, Jiang X, Tonta M, Lam R, Wickremasinghe H, Zhao J, Wang J, Coleman HA, Formosa LE, Velkov T, Parkington HC, Combes AN, Rosenbluh J, Li J. Lu J, et al. Among authors: jiang x. Cell Mol Life Sci. 2022 May 15;79(6):296. doi: 10.1007/s00018-022-04316-z. Cell Mol Life Sci. 2022. PMID: 35570209 Free PMC article.
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