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Page 1
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.
Ullah TR, Johansen MD, Balka KR, Ambrose RL, Gearing LJ, Roest J, Vivian JP, Sapkota S, Jayasekara WSN, Wenholz DS, Aldilla VR, Zeng J, Miemczyk S, Nguyen DH, Hansbro NG, Venkatraman R, Kang JH, Pang ES, Thomas BJ, Alharbi AS, Rezwan R, O'Keeffe M, Donald WA, Ellyard JI, Wong W, Kumar N, Kile BT, Vinuesa CG, Kelly GE, Laczka OF, Hansbro PM, De Nardo D, Gantier MP. Ullah TR, et al. Among authors: jayasekara wsn. Nat Commun. 2023 Sep 18;14(1):5666. doi: 10.1038/s41467-023-41381-9. Nat Commun. 2023. PMID: 37723181 Free PMC article.
A STAT3 protein complex required for mitochondrial mRNA stability and cancer.
Fernando CD, Jayasekara WSN, Inampudi C, Kohonen-Corish MRJ, Cooper WA, Beilharz TH, Josephs TM, Garama DJ, Gough DJ. Fernando CD, et al. Among authors: jayasekara wsn. Cell Rep. 2023 Sep 26;42(9):113033. doi: 10.1016/j.celrep.2023.113033. Epub 2023 Sep 12. Cell Rep. 2023. PMID: 37703176 Free article.
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Cochrane CR, Vaghjiani V, Szczepny A, Jayasekara WSN, Gonzalez-Rajal A, Kikuchi K, McCaughan GW, Burgess A, Gough DJ, Watkins DN, Cain JE. Cochrane CR, et al. Among authors: jayasekara wsn. J Clin Invest. 2020 Aug 3;130(8):4006-4018. doi: 10.1172/JCI132513. J Clin Invest. 2020. PMID: 32568216 Free PMC article.
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.
Vaghjiani VG, Cochrane CR, Jayasekara WSN, Chong WC, Szczepny A, Kumar B, Martelotto LG, McCaw A, Carey K, Kansara M, Thomas DM, Walkley C, Mudge S, Gough DJ, Downie PA, Peacock CD, Matsui W, Watkins DN, Cain JE. Vaghjiani VG, et al. Among authors: jayasekara wsn. Oncogene. 2023 Nov;42(47):3529-3541. doi: 10.1038/s41388-023-02864-7. Epub 2023 Oct 16. Oncogene. 2023. PMID: 37845394 Free PMC article.
The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN. Szczepny A, et al. Among authors: jayasekara wsn. Oncogene. 2018 Apr;37(14):1939-1948. doi: 10.1038/s41388-017-0022-1. Epub 2018 Jan 25. Oncogene. 2018. PMID: 29367758 Free PMC article.
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.
Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN. Leong TL, et al. Among authors: jayasekara wsn. Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22. Oncogene. 2019. PMID: 30348992 Free PMC article.
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.
Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN. Marini KD, et al. Among authors: jayasekara wsn. Sci Transl Med. 2018 Jul 25;10(451):eaat3504. doi: 10.1126/scitranslmed.aat3504. Sci Transl Med. 2018. PMID: 30045976
21 results