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Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1.
Betts A, Clark T, Jasper P, Tolsma J, van der Graaf PH, Graziani EI, Rosfjord E, Sung M, Ma D, Barletta F. Betts A, et al. Among authors: jasper p. J Pharmacokinet Pharmacodyn. 2020 Oct;47(5):513-526. doi: 10.1007/s10928-020-09702-3. Epub 2020 Jul 24. J Pharmacokinet Pharmacodyn. 2020. PMID: 32710210 Free PMC article.
A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
Jones HM, Tolsma J, Zhang Z, Jasper P, Luo H, Weber GL, Wright K, Bard J, Bell R, Messing D, Kelleher K, Piche-Nicholas N, Webster R. Jones HM, et al. Among authors: jasper p. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):534-541. doi: 10.1002/psp4.12547. Epub 2020 Aug 17. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32697437 Free PMC article.
A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
Abrams R, Kaddi CD, Tao M, Leiser RJ, Simoni G, Reali F, Tolsma J, Jasper P, van Rijn Z, Li J, Niesner B, Barrett JS, Marchetti L, Peterschmitt MJ, Azer K, Neves-Zaph S. Abrams R, et al. Among authors: jasper p. CPT Pharmacometrics Syst Pharmacol. 2020 Jul;9(7):374-383. doi: 10.1002/psp4.12506. Epub 2020 Jun 19. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32558397 Free PMC article.
Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy.
Nguyen HQ, Iskenderian A, Ehmann D, Jasper P, Zhang Z, Rong H, Welty D, Narayanan R. Nguyen HQ, et al. Among authors: jasper p. CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):342-352. doi: 10.1002/psp4.12518. Epub 2020 Jun 20. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32419339 Free PMC article.
57 results