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Page 1
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Bürli RW, Rubinsztein DC. Wrobel L, et al. Among authors: jarvis r. Nat Commun. 2022 Jul 16;13(1):4146. doi: 10.1038/s41467-022-31905-0. Nat Commun. 2022. PMID: 35842429 Free PMC article.
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.
Jarvis R, Josephine Ng SF, Nathanson AJ, Cardarelli RA, Abiraman K, Wade F, Evans-Strong A, Fernandez-Campa MP, Deeb TZ, Smalley JL, Jamier T, Gurrell IK, McWilliams L, Kawatkar A, Conway LC, Wang Q, Burli RW, Brandon NJ, Chessell IP, Goldman AJ, Maguire JL, Moss SJ. Jarvis R, et al. Cell Rep Med. 2023 Mar 21;4(3):100957. doi: 10.1016/j.xcrm.2023.100957. Epub 2023 Mar 7. Cell Rep Med. 2023. PMID: 36889319 Free PMC article.
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
ElBeck Z, Hossain MB, Siga H, Oskolkov N, Karlsson F, Lindgren J, Walentinsson A, Koppenhöfer D, Jarvis R, Bürli R, Jamier T, Franssen E, Firth M, Degasperi A, Bendtsen C, Menzies RI, Streckfuss-Bömeke K, Kohlhaas M, Nickel AG, Lund LH, Maack C, Végvári Á, Betsholtz C. ElBeck Z, et al. Among authors: jarvis r. Nat Commun. 2024 Mar 20;15(1):2358. doi: 10.1038/s41467-024-46384-8. Nat Commun. 2024. PMID: 38509128 Free PMC article.
A solution scan of societal options to reduce transmission and spread of respiratory viruses: SARS-CoV-2 as a case study.
Sutherland WJ, Taylor NG, Aldridge DC, Martin P, Rhodes C, Shackelford G, Beard S, Belfield H, Bladon AJ, Brick C, Christie AP, Dobson AP, Downey H, Hood ASC, Hua F, Hughes AC, Jarvis RM, MacFarlane D, Morgan WH, Mupepele AC, Marciniak SJ, Nelson C, Ó hÉigeartaigh S, Rios Rojas C, Sainsbury KA, Smith RK, Sundaram LS, Thornton A, Watkins J, White TB, Willott K, Petrovan SO. Sutherland WJ, et al. J Biosaf Biosecur. 2021 Dec;3(2):84-90. doi: 10.1016/j.jobb.2021.08.003. Epub 2021 Sep 15. J Biosaf Biosecur. 2021. PMID: 34541465 Free PMC article.
Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT).
Carlile O, Briggs A, Henderson AD, Butler-Cole BFC, Tazare J, Tomlinson LA, Marks M, Jit M, Lin LY, Bates C, Parry J, Bacon SCJ, Dillingham I, Dennison WA, Costello RE, Walker AJ, Hulme W, Goldacre B, Mehrkar A, MacKenna B; OpenSAFELY Collaborative; Herrett E, Eggo RM. Carlile O, et al. Lancet Reg Health Eur. 2024 Apr 24;40:100908. doi: 10.1016/j.lanepe.2024.100908. eCollection 2024 May. Lancet Reg Health Eur. 2024. PMID: 38689605 Free PMC article.
Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.
Gutierrez Del Arroyo A, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S, Brealey D, Pearse RM, Ackland GL; SPACE trial investigators. Gutierrez Del Arroyo A, et al. Br J Anaesth. 2024 May;132(5):857-866. doi: 10.1016/j.bja.2024.01.010. Epub 2024 Feb 9. Br J Anaesth. 2024. PMID: 38341283 Free article. Clinical Trial.
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group; Horby PW, Peto L, Staplin N, Campbell M, Pessoa-Amorim G, Mafham M, Emberson JR, Stewart R, Prudon B, Uriel A, Green CA, Dhasmana DJ, Malein F, Majumdar J, Collini P, Shurmer J, Yates B, Baillie JK, Buch MH, Day J, Faust SN, Jaki T, Jeffery K, Juszczak E, Knight M, Lim WS, Montgomery A, Mumford A, Rowan K, Thwaites G, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. Nat Commun. 2024 Jan 31;15(1):924. doi: 10.1038/s41467-023-43644-x. Nat Commun. 2024. PMID: 38296965 Free PMC article. Clinical Trial.
224 results