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Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
Sinha SR, Haileselassie Y, Nguyen LP, Tropini C, Wang M, Becker LS, Sim D, Jarr K, Spear ET, Singh G, Namkoong H, Bittinger K, Fischbach MA, Sonnenburg JL, Habtezion A. Sinha SR, et al. Among authors: jarr k. Cell Host Microbe. 2020 Apr 8;27(4):659-670.e5. doi: 10.1016/j.chom.2020.01.021. Epub 2020 Feb 25. Cell Host Microbe. 2020. PMID: 32101703 Free PMC article.
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis.
Jarr KU, Ye J, Kojima Y, Ye Z, Gao H, Schmid S, Luo L, Baylis RA, Lotfi M, Lopez N, Eberhard AV, Smith BR, Weissman IL, Maegdefessel L, Leeper NJ. Jarr KU, et al. Nat Cardiovasc Res. 2022 Mar;1(3):253-262. doi: 10.1038/s44161-022-00023-x. Epub 2022 Mar 7. Nat Cardiovasc Res. 2022. PMID: 35990913 Free PMC article.
Effect of CD47 Blockade on Vascular Inflammation.
Jarr KU, Nakamoto R, Doan BH, Kojima Y, Weissman IL, Advani RH, Iagaru A, Leeper NJ. Jarr KU, et al. N Engl J Med. 2021 Jan 28;384(4):382-383. doi: 10.1056/NEJMc2029834. N Engl J Med. 2021. PMID: 33503349 Free PMC article. No abstract available.
Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability.
Tsantilas P, Lao S, Wu Z, Eberhard A, Winski G, Vaerst M, Nanda V, Wang Y, Kojima Y, Ye J, Flores A, Jarr KU, Pelisek J, Eckstein HH, Matic L, Hedin U, Tsao PS, Paloschi V, Maegdefessel L, Leeper NJ. Tsantilas P, et al. Among authors: jarr ku. Cardiovasc Res. 2021 Dec 17;117(14):2767-2780. doi: 10.1093/cvr/cvab014. Cardiovasc Res. 2021. PMID: 33471078 Free PMC article.
18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.
Jarr KU, Ye J, Kojima Y, Nanda V, Flores AM, Tsantilas P, Wang Y, Hosseini-Nassab N, Eberhard AV, Lotfi M, Käller M, Smith BR, Maegdefessel L, Leeper NJ. Jarr KU, et al. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2821-2828. doi: 10.1161/ATVBAHA.120.315239. Epub 2020 Oct 22. Arterioscler Thromb Vasc Biol. 2020. PMID: 33086865 Free PMC article.
Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.
Wang Y, Nanda V, Direnzo D, Ye J, Xiao S, Kojima Y, Howe KL, Jarr KU, Flores AM, Tsantilas P, Tsao N, Rao A, Newman AAC, Eberhard AV, Priest JR, Ruusalepp A, Pasterkamp G, Maegdefessel L, Miller CL, Lind L, Koplev S, Björkegren JLM, Owens GK, Ingelsson E, Weissman IL, Leeper NJ. Wang Y, et al. Among authors: jarr ku. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15818-15826. doi: 10.1073/pnas.2006348117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541024 Free PMC article.
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