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Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.
Al-Eisawi Z, Stefani C, Jansson PJ, Arvind A, Sharpe PC, Basha MT, Iskander GM, Kumar N, Kovacevic Z, Lane DJ, Sahni S, Bernhardt PV, Richardson DR, Kalinowski DS. Al-Eisawi Z, et al. Among authors: jansson pj. J Med Chem. 2016 Jan 14;59(1):294-312. doi: 10.1021/acs.jmedchem.5b01399. Epub 2015 Dec 31. J Med Chem. 2016. PMID: 26645570
The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity.
Mladĕnka P, Kalinowski DS, Haskova P, Bobrovová Z, Hrdina R, Simůnek T, Nachtigal P, Semecký V, Vávrová J, Holeckova M, Palicka V, Mazurová Y, Jansson PJ, Richardson DR. Mladĕnka P, et al. Among authors: jansson pj. Chem Res Toxicol. 2009 Jan;22(1):208-17. doi: 10.1021/tx800331j. Chem Res Toxicol. 2009. PMID: 19172757
Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
Quach P, Gutierrez E, Basha MT, Kalinowski DS, Sharpe PC, Lovejoy DB, Bernhardt PV, Jansson PJ, Richardson DR. Quach P, et al. Among authors: jansson pj. Mol Pharmacol. 2012 Jul;82(1):105-14. doi: 10.1124/mol.112.078964. Epub 2012 Apr 16. Mol Pharmacol. 2012. PMID: 22508546
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
Lovejoy DB, Sharp DM, Seebacher N, Obeidy P, Prichard T, Stefani C, Basha MT, Sharpe PC, Jansson PJ, Kalinowski DS, Bernhardt PV, Richardson DR. Lovejoy DB, et al. Among authors: jansson pj. J Med Chem. 2012 Aug 23;55(16):7230-44. doi: 10.1021/jm300768u. Epub 2012 Aug 3. J Med Chem. 2012. PMID: 22861499
86 results