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Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies.
Kovalevich J, Cornec AS, Yao Y, James M, Crowe A, Lee VM, Trojanowski JQ, Smith AB 3rd, Ballatore C, Brunden KR. Kovalevich J, et al. J Pharmacol Exp Ther. 2016 May;357(2):432-50. doi: 10.1124/jpet.115.231175. Epub 2016 Mar 15. J Pharmacol Exp Ther. 2016. PMID: 26980057 Free PMC article.
Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.
Oukoloff K, Nzou G, Varricchio C, Lucero B, Alle T, Kovalevich J, Monti L, Cornec AS, Yao Y, James MJ, Trojanowski JQ, Lee VM, Smith AB 3rd, Brancale A, Brunden KR, Ballatore C. Oukoloff K, et al. Among authors: james mj. J Med Chem. 2021 Jan 28;64(2):1073-1102. doi: 10.1021/acs.jmedchem.0c01605. Epub 2021 Jan 7. J Med Chem. 2021. PMID: 33411523 Free PMC article.
Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.
Ballatore C, Crowe A, Piscitelli F, James M, Lou K, Rossidivito G, Yao Y, Trojanowski JQ, Lee VM, Brunden KR, Smith AB 3rd. Ballatore C, et al. Bioorg Med Chem. 2012 Jul 15;20(14):4451-61. doi: 10.1016/j.bmc.2012.05.027. Epub 2012 May 23. Bioorg Med Chem. 2012. PMID: 22717239 Free PMC article.
211 results