Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase.
Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL.
Delker SL, et al. Among authors: jamal j.
Biochemistry. 2010 Dec 28;49(51):10803-10. doi: 10.1021/bi1013479. Epub 2010 Dec 7.
Biochemistry. 2010.
PMID: 21138269
Free PMC article.
This prompted us to design and synthesize symmetric "double-headed" inhibitors with an aminopyridine at each end of a bridging ring structure [Xue, F., Delker, S. L., Li, H., Fang, J., Jamal, J., Martasek, P., Roman, L. J., Poulos, T. L., and Silverman …
This prompted us to design and synthesize symmetric "double-headed" inhibitors with an aminopyridine at each end of a bridging ring structur …