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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.
Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Olagnier D, et al. Among authors: jakobsen mr. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. Nat Commun. 2018. PMID: 30158636 Free PMC article.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Holm CK, et al. Among authors: jakobsen mr. Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350. Nat Immunol. 2012. PMID: 22706339 Free PMC article.
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Horan KA, et al. Among authors: jakobsen mr. J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23. J Immunol. 2013. PMID: 23345332 Free PMC article.
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.
Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J, Laustsen A, Hansen K, Ostergaard L, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR. Jakobsen MR, et al. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4571-80. doi: 10.1073/pnas.1311669110. Epub 2013 Oct 23. Proc Natl Acad Sci U S A. 2013. PMID: 24154727 Free PMC article.
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.
Berg RK, Rahbek SH, Kofod-Olsen E, Holm CK, Melchjorsen J, Jensen DG, Hansen AL, Jørgensen LB, Ostergaard L, Tolstrup M, Larsen CS, Paludan SR, Jakobsen MR, Mogensen TH. Berg RK, et al. Among authors: jakobsen mr. PLoS One. 2014 Jan 3;9(1):e84513. doi: 10.1371/journal.pone.0084513. eCollection 2014. PLoS One. 2014. PMID: 24404168 Free PMC article.
Innate immune sensing of HIV-1 infection.
Jakobsen MR, Olagnier D, Hiscott J. Jakobsen MR, et al. Curr Opin HIV AIDS. 2015 Mar;10(2):96-102. doi: 10.1097/COH.0000000000000129. Curr Opin HIV AIDS. 2015. PMID: 25485569 Review.
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR. Sun C, et al. Among authors: jakobsen mr. J Immunol. 2015 Feb 15;194(4):1819-31. doi: 10.4049/jimmunol.1402495. Epub 2015 Jan 16. J Immunol. 2015. PMID: 25595793 Free PMC article.
Histone deacetylase inhibitor romidepsin inhibits de novo HIV-1 infections.
Jønsson KL, Tolstrup M, Vad-Nielsen J, Kjær K, Laustsen A, Andersen MN, Rasmussen TA, Søgaard OS, Østergaard L, Denton PW, Jakobsen MR. Jønsson KL, et al. Among authors: jakobsen mr. Antimicrob Agents Chemother. 2015 Jul;59(7):3984-94. doi: 10.1128/AAC.00574-15. Epub 2015 Apr 20. Antimicrob Agents Chemother. 2015. PMID: 25896701 Free PMC article.
84 results