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Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer.
Thiyagarajan T, Ponnusamy S, Hwang DJ, He Y, Asemota S, Young KL, Johnson DL, Bocharova V, Zhou W, Jain AK, Petricoin EF, Yin Z, Pfeffer LM, Miller DD, Narayanan R. Thiyagarajan T, et al. Among authors: jain ak. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2211832120. doi: 10.1073/pnas.2211832120. Epub 2022 Dec 28. Proc Natl Acad Sci U S A. 2023. PMID: 36577061 Free PMC article.
Trim24 targets endogenous p53 for degradation.
Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC. Allton K, et al. Among authors: jain ak. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612-6. doi: 10.1073/pnas.0813177106. Epub 2009 Jun 25. Proc Natl Acad Sci U S A. 2009. PMID: 19556538 Free PMC article.
P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis.
Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, Song JH, Mak CSL, Park J, Zheng SE, Huang A, Ma X, Chen R, Chang Q, Logothetis CJ, Jain AK, Lin SH, Katayama H, Hanash S, Wang G. Zhu M, et al. Among authors: jain ak. Oncogene. 2021 Oct;40(41):6049-6056. doi: 10.1038/s41388-021-02000-3. Epub 2021 Sep 1. Oncogene. 2021. PMID: 34471235 Free PMC article.
Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy.
Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Liang J, et al. Among authors: jain ak. Cancer Immunol Res. 2020 Jul;8(7):952-965. doi: 10.1158/2326-6066.CIR-19-0159. Epub 2020 Apr 7. Cancer Immunol Res. 2020. PMID: 32265228 Free PMC article.
Bromodomain Histone Readers and Cancer.
Jain AK, Barton MC. Jain AK, et al. J Mol Biol. 2017 Jun 30;429(13):2003-2010. doi: 10.1016/j.jmb.2016.11.020. Epub 2016 Nov 24. J Mol Biol. 2017. PMID: 27890782 Review.
Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL.
Piya S, Yang Y, Bhattacharya S, Sharma P, Ma H, Mu H, He H, Ruvolo V, Baran N, Davis RE, Jain AK, Konopleava M, Kantarjian H, Andreeff M, You MJ, Borthakur G. Piya S, et al. Among authors: jain ak. Leukemia. 2022 May;36(5):1261-1273. doi: 10.1038/s41375-022-01516-1. Epub 2022 Feb 16. Leukemia. 2022. PMID: 35173274 Free PMC article.
1,398 results