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Year Number of Results
2004 1
2008 1
2010 3
2011 8
2012 8
2013 4
2014 1
2015 2
2016 9
2017 9
2018 12
2019 9
2020 10
2021 14
2022 8
2023 8
2024 1

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101 results

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Page 1
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Pyka P, Haberek W, Więcek M, Szymanska E, Ali W, Cios A, Jastrzębska-Więsek M, Satała G, Podlewska S, Di Giacomo S, Di Sotto A, Garbo S, Karcz T, Lambona C, Marocco F, Latacz G, Sudoł-Tałaj S, Mordyl B, Głuch-Lutwin M, Siwek A, Czarnota-Łydka K, Gogola D, Olejarz-Maciej A, Wilczyńska-Zawal N, Honkisz-Orzechowska E, Starek M, Dąbrowska M, Kucwaj-Brysz K, Fioravanti R, Nasim MJ, Hittinger M, Partyka A, Wesołowska A, Battistelli C, Zwergel C, Handzlik J. Pyka P, et al. Among authors: handzlik j. J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8. J Med Chem. 2024. PMID: 38190615 Free PMC article.
Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents.
Sudoł-Tałaj S, Kucwaj-Brysz K, Podlewska S, Kurczab R, Satała G, Mordyl B, Głuch-Lutwin M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Czarnota-Łydka K, Kurowska K, Kubacka M, Żesławska E, Nitek W, Olejarz-Maciej A, Doroz-Płonka A, Partyka A, Latacz G, Wesołowska A, Handzlik J. Sudoł-Tałaj S, et al. Among authors: handzlik j. Eur J Med Chem. 2023 Nov 15;260:115756. doi: 10.1016/j.ejmech.2023.115756. Epub 2023 Aug 24. Eur J Med Chem. 2023. PMID: 37657272 Free article.
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J. Czarnota-Łydka K, et al. Among authors: handzlik j. Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30. Eur J Med Chem. 2023. PMID: 37567058 Free article.
Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Stępnicki P, Targowska-Duda KM, Martínez AL, Zięba A, Wronikowska-Denysiuk O, Wróbel MZ, Bartyzel A, Trzpil A, Wróbel TM, Chodkowski A, Mirecka K, Karcz T, Szczepańska K, Loza MI, Budzyńska B, Turło J, Handzlik J, Fornal E, Poleszak E, Castro M, Kaczor AA. Stępnicki P, et al. Among authors: handzlik j. Eur J Med Chem. 2023 Apr 5;252:115285. doi: 10.1016/j.ejmech.2023.115285. Epub 2023 Mar 17. Eur J Med Chem. 2023. PMID: 37027998
Relationships between Molecular Characteristics of Novel Organic Selenium Compounds and the Formation of Sulfur Compounds in Selenium Biofortified Kale Sprouts.
Zagrodzki P, Wiesner A, Marcinkowska M, Jamrozik M, Domínguez-Álvarez E, Bierła K, Łobiński R, Szpunar J, Handzlik J, Galanty A, Gorinstein S, Paśko P. Zagrodzki P, et al. Among authors: handzlik j. Molecules. 2023 Feb 22;28(5):2062. doi: 10.3390/molecules28052062. Molecules. 2023. PMID: 36903308 Free PMC article.
New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands.
Łażewska D, Więcek M, Satała G, Chałupnik P, Żesławska E, Honkisz-Orzechowska E, Tarasek M, Latacz G, Nitek W, Szymańska E, Handzlik J. Łażewska D, et al. Among authors: handzlik j. Molecules. 2023 Jan 22;28(3):1108. doi: 10.3390/molecules28031108. Molecules. 2023. PMID: 36770774 Free PMC article.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Godyń J, Zaręba P, Stary D, Kaleta M, Kuder KJ, Latacz G, Mogilski S, Reiner-Link D, Frank A, Doroz-Płonka A, Olejarz-Maciej A, Sudoł-Tałaj S, Nolte T, Handzlik J, Stark H, Więckowska A, Malawska B, Kieć-Kononowicz K, Łażewska D, Bajda M. Godyń J, et al. Among authors: handzlik j. Molecules. 2022 Dec 28;28(1):238. doi: 10.3390/molecules28010238. Molecules. 2022. PMID: 36615435 Free PMC article.
101 results