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The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder.
Recourt K, de Boer P, Zuiker R, Luthringer R, Kent J, van der Ark P, Van Hove I, van Gerven J, Jacobs G, van Nueten L, Drevets W. Recourt K, et al. Among authors: jacobs g. Transl Psychiatry. 2019 Sep 3;9(1):216. doi: 10.1038/s41398-019-0553-z. Transl Psychiatry. 2019. PMID: 31481683 Free PMC article. Clinical Trial.
Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
Smarius LJ, Jacobs GE, Hoeberechts-Lefrandt DH, de Kam ML, van der Post JP, de Rijk R, van Pelt J, Schoemaker RC, Zitman FG, van Gerven JM, Gijsman HJ. Smarius LJ, et al. Among authors: jacobs ge. J Psychopharmacol. 2008 Jun;22(4):426-33. doi: 10.1177/0269881107082025. Epub 2008 Feb 28. J Psychopharmacol. 2008. PMID: 18308795 Clinical Trial.
Hypothalamic glutamate levels following serotonergic stimulation: a pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers.
Jacobs GE, der Grond Jv, Teeuwisse WM, Langeveld TJ, van Pelt J, Verhagen JC, de Kam ML, Cohen AF, Zitman FG, van Gerven JM. Jacobs GE, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):486-91. doi: 10.1016/j.pnpbp.2010.01.019. Epub 2010 Feb 4. Prog Neuropsychopharmacol Biol Psychiatry. 2010. PMID: 20138102 Clinical Trial.
Desmopressin as a pharmacological tool in vasopressinergic hypothalamus-pituitary-adrenal axis modulation: neuroendocrine, cardiovascular and coagulatory effects.
Jacobs GE, Hulskotte EG, van Gerven JM, Zuurman L, de Kam ML, Elassaiss-Schaap J, Ruigt G, van Pelt J, Peeters BW, Peeters PA, Burggraaf J. Jacobs GE, et al. J Psychopharmacol. 2011 Mar;25(3):353-60. doi: 10.1177/0269881109358203. Epub 2010 Feb 8. J Psychopharmacol. 2011. PMID: 20142306 Clinical Trial.
Metoclopramide as pharmacological tool to assess vasopressinergic co-activation of the hypothalamus-pituitary-adrenal (HPA) axis: a study in healthy volunteers.
Jacobs GE, Hulskotte EG, de Kam ML, Zha G, Jiang J, Hu P, Zhao Q, van Pelt J, Goekoop JG, Zitman FG, van Gerven JM. Jacobs GE, et al. Eur Neuropsychopharmacol. 2010 Dec;20(12):866-74. doi: 10.1016/j.euroneuro.2010.06.009. Epub 2010 Jul 23. Eur Neuropsychopharmacol. 2010. PMID: 20655180 Clinical Trial.
987 results