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Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Balmus G, Larrieu D, Barros AC, Collins C, Abrudan M, Demir M, Geisler NJ, Lelliott CJ, White JK, Karp NA, Atkinson J, Kirton A, Jacobsen M, Clift D, Rodriguez R; Sanger Mouse Genetics Project; Adams DJ, Jackson SP. Balmus G, et al. Among authors: jackson sp. Nat Commun. 2018 Apr 27;9(1):1700. doi: 10.1038/s41467-018-03770-3. Nat Commun. 2018. PMID: 29703891 Free PMC article.
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.
McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project; Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ. McIntyre RE, et al. Among authors: jackson sp. PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15. PLoS Genet. 2012. PMID: 23166506 Free PMC article.
CtIP tetramer assembly is required for DNA-end resection and repair.
Davies OR, Forment JV, Sun M, Belotserkovskaya R, Coates J, Galanty Y, Demir M, Morton CR, Rzechorzek NJ, Jackson SP, Pellegrini L. Davies OR, et al. Among authors: jackson sp. Nat Struct Mol Biol. 2015 Feb;22(2):150-157. doi: 10.1038/nsmb.2937. Epub 2015 Jan 5. Nat Struct Mol Biol. 2015. PMID: 25558984 Free PMC article.
Synthetic viability genomic screening defines Sae2 function in DNA repair.
Puddu F, Oelschlaegel T, Guerini I, Geisler NJ, Niu H, Herzog M, Salguero I, Ochoa-Montaño B, Viré E, Sung P, Adams DJ, Keane TM, Jackson SP. Puddu F, et al. Among authors: jackson sp. EMBO J. 2015 Jun 3;34(11):1509-22. doi: 10.15252/embj.201590973. Epub 2015 Apr 21. EMBO J. 2015. PMID: 25899817 Free PMC article.
Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.
Schmidt CK, Galanty Y, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Cornwell M, Beli P, Jackson SP. Schmidt CK, et al. Among authors: jackson sp. Nat Cell Biol. 2015 Nov;17(11):1458-1470. doi: 10.1038/ncb3260. Epub 2015 Oct 26. Nat Cell Biol. 2015. PMID: 26502057 Free PMC article.
489 results