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Page 1
Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A.
Jürjens G, Schuler SMM, Kurz M, Petit S, Couturier C, Jeannot F, Nguyen F, Wende RC, Hammann PE, Wilson DN, Bacqué E, Pöverlein C, Bauer A. Jürjens G, et al. Angew Chem Int Ed Engl. 2018 Sep 10;57(37):12157-12161. doi: 10.1002/anie.201805901. Epub 2018 Aug 13. Angew Chem Int Ed Engl. 2018. PMID: 30004165
Total Synthesis of GE81112A: An Orthoester-Based Approach.
Fayad S, Jafari A, Schuler SMM, Kurz M, Plettenburg O, Hammann PE, Bauer A, Jürjens G, Pöverlein C. Fayad S, et al. Among authors: jurjens g. J Org Chem. 2023 May 5;88(9):5597-5608. doi: 10.1021/acs.joc.3c00094. Epub 2023 Apr 6. J Org Chem. 2023. PMID: 37023463 Free PMC article.
Lessons from the synthetic chemist nature.
Jürjens G, Kirschning A, Candito DA. Jürjens G, et al. Nat Prod Rep. 2015 May;32(5):723-37. doi: 10.1039/c4np00160e. Nat Prod Rep. 2015. PMID: 25728458 Review.
Bioreduction of aryl azides during mutasynthesis of new ansamitocins.
Mancuso L, Jürjens G, Hermane J, Harmrolfs K, Eichner S, Fohrer J, Collisi W, Sasse F, Kirschning A. Mancuso L, et al. Among authors: jurjens g. Org Lett. 2013 Sep 6;15(17):4442-5. doi: 10.1021/ol401989e. Epub 2013 Aug 27. Org Lett. 2013. PMID: 23981134
Synthesis of a cytotoxic ansamycin hybrid.
Jürjens G, Kirschning A. Jürjens G, et al. Org Lett. 2014 Jun 6;16(11):3000-3. doi: 10.1021/ol5011278. Epub 2014 May 29. Org Lett. 2014. PMID: 24874463
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K. Brenke JK, et al. Among authors: jurjens g. J Biol Chem. 2018 Aug 24;293(34):13191-13203. doi: 10.1074/jbc.RA118.002649. Epub 2018 Jun 27. J Biol Chem. 2018. PMID: 29950522 Free PMC article.
Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens.
Schuler SMM, Jürjens G, Marker A, Hemmann U, Rey A, Yvon S, Lagrevol M, Hamiti M, Nguyen F, Hirsch R, Pöverlein C, Vilcinskas A, Hammann P, Wilson DN, Mourez M, Coyne S, Bauer A. Schuler SMM, et al. Among authors: jurjens g. Microbiol Spectr. 2023 Jun 15;11(3):e0224722. doi: 10.1128/spectrum.02247-22. Epub 2023 May 4. Microbiol Spectr. 2023. PMID: 37140391 Free PMC article.