Jørgensen PT - Search Results

1

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures.

Pabon-Martinez YV, Xu Y, Villa A, Lundin KE, Geny S, Nguyen CH, Pedersen EB, Jørgensen PT, Wengel J, Nilsson L, Smith CIE, Zain R. Pabon-Martinez YV, et al. Among authors: jorgensen pt. Sci Rep. 2017 Sep 8;7(1):11043. doi: 10.1038/s41598-017-09147-8. Sci Rep. 2017. PMID: 28887512 Free PMC article.

2

Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.

El-Brollosy NR, Jørgensen PT, Dahan B, Boel AM, Pedersen EB, Nielsen C. El-Brollosy NR, et al. Among authors: jorgensen pt. J Med Chem. 2002 Dec 19;45(26):5721-6. doi: 10.1021/jm020949r. J Med Chem. 2002. PMID: 12477355

3

Facile route for the synthesis of the iminosugar nucleoside (3R,4R)-1-(pyren-1-yl)-4-(hydroxymethyl)pyrrolidin-3-ol.

Hassan AA, Jørgensen PT, Stein PC, Fattah ME, el-Gawad II, Pedersen EB. Hassan AA, et al. Among authors: jorgensen pt. Carbohydr Res. 2004 Jun 1;339(8):1565-8. doi: 10.1016/j.carres.2004.03.022. Carbohydr Res. 2004. PMID: 15178403

4

Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.

Petersen L, Jørgensen PT, Nielsen C, Hansen TH, Nielsen J, Pedersen EB. Petersen L, et al. Among authors: jorgensen pt. J Med Chem. 2005 Feb 24;48(4):1211-20. doi: 10.1021/jm040845b. J Med Chem. 2005. PMID: 15715487

5

Synthesis of 6-(3,5-dichlorobenzyl) derivatives as isosteric analogues of the HIV drug 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil (GCA-186).

Sørensen ER, El-Brollosy NR, Jørgensen PT, Pedersen EB, Nielsen C. Sørensen ER, et al. Among authors: jorgensen pt. Arch Pharm (Weinheim). 2005 Jul;338(7):299-304. doi: 10.1002/ardp.200400952. Arch Pharm (Weinheim). 2005. PMID: 15996003

6

Triplex glue by synthesizing conjugated flexible intercalators.

Pedersen EB, Osman AM, Globisch D, Paramasivam M, Cogoi S, Bomholt N, Jørgensen PT, Xodo LE, Filichev VV. Pedersen EB, et al. Among authors: jorgensen pt. Nucleic Acids Symp Ser (Oxf). 2008;(52):37-8. doi: 10.1093/nass/nrn019. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776241

7

Using an aryl phenanthroimidazole moiety as a conjugated flexible intercalator to improve the hybridization efficiency of a triplex-forming oligonucleotide.

Osman AM, Jørgensen PT, Bomholt N, Pedersen EB. Osman AM, et al. Among authors: jorgensen pt. Bioorg Med Chem. 2008 Dec 1;16(23):9937-47. doi: 10.1016/j.bmc.2008.10.037. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18977149

8

Synthesis of locked pyranosyl nucleic acid (LpNA).

Bomholt N, Jørgensen PT, Pedersen EB. Bomholt N, et al. Among authors: jorgensen pt. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7376-8. doi: 10.1016/j.bmcl.2011.10.005. Epub 2011 Oct 8. Bioorg Med Chem Lett. 2011. PMID: 22041061

9

Conjugation of a 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-1H-indole intercalator to a triplex oligonucleotide and to a three-way junction.

Fatthalla MI, Elkholy YM, Abbas NS, Mandour AH, Jørgensen PT, Bomholt N, Pedersen EB. Fatthalla MI, et al. Among authors: jorgensen pt. Bioorg Med Chem. 2012 Jan 1;20(1):207-14. doi: 10.1016/j.bmc.2011.11.013. Epub 2011 Nov 13. Bioorg Med Chem. 2012. PMID: 22154560

10

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.

Moreno PM, Geny S, Pabon YV, Bergquist H, Zaghloul EM, Rocha CS, Oprea II, Bestas B, Andaloussi SE, Jørgensen PT, Pedersen EB, Lundin KE, Zain R, Wengel J, Smith CI. Moreno PM, et al. Among authors: jorgensen pt. Nucleic Acids Res. 2013 Mar 1;41(5):3257-73. doi: 10.1093/nar/gkt007. Epub 2013 Jan 23. Nucleic Acids Res. 2013. PMID: 23345620 Free PMC article.

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