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Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment.
Rebstock AS, Wiedmann M, Stelte-Ludwig B, Wong H, Johnson AJ, Izumi R, Hamdy A, Lerchen HG. Rebstock AS, et al. Among authors: izumi r. Front Pharmacol. 2024 Mar 1;15:1358393. doi: 10.3389/fphar.2024.1358393. eCollection 2024. Front Pharmacol. 2024. PMID: 38495100 Free PMC article.
Nationwide survey of patients with multisystem proteinopathy in Japan.
Yamashita S, Takahashi Y, Hashimoto J, Murakami A, Nakamura R, Katsuno M, Izumi R, Suzuki N, Warita H, Aoki M; Japan MSP Study Group. Yamashita S, et al. Among authors: izumi r. Ann Clin Transl Neurol. 2024 Apr;11(4):938-945. doi: 10.1002/acn3.52011. Epub 2024 Jan 29. Ann Clin Transl Neurol. 2024. PMID: 38287512 Free PMC article.
Discovery of VIP236, an αvβ3-Targeted Small-Molecule-Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors.
Lerchen HG, Stelte-Ludwig B, Heroult M, Zubov D, Gericke KM, Wong H, Frigault MM, Johnson AJ, Izumi R, Hamdy A. Lerchen HG, et al. Among authors: izumi r. Cancers (Basel). 2023 Sep 1;15(17):4381. doi: 10.3390/cancers15174381. Cancers (Basel). 2023. PMID: 37686656 Free PMC article.
348 results