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UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
Gozdecka M, Meduri E, Mazan M, Tzelepis K, Dudek M, Knights AJ, Pardo M, Yu L, Choudhary JS, Metzakopian E, Iyer V, Yun H, Park N, Varela I, Bautista R, Collord G, Dovey O, Garyfallos DA, De Braekeleer E, Kondo S, Cooper J, Göttgens B, Bullinger L, Northcott PA, Adams D, Vassiliou GS, Huntly BJP. Gozdecka M, et al. Among authors: iyer v. Nat Genet. 2018 Jun;50(6):883-894. doi: 10.1038/s41588-018-0114-z. Epub 2018 May 7. Nat Genet. 2018. PMID: 29736013 Free PMC article.
A population-based analysis of germline BAP1 mutations in melanoma.
O'Shea SJ, Robles-Espinoza CD, McLellan L, Harrigan J, Jacq X, Hewinson J, Iyer V, Merchant W, Elliott F, Harland M, Bishop DT, Newton-Bishop JA, Adams DJ. O'Shea SJ, et al. Among authors: iyer v. Hum Mol Genet. 2017 Feb 15;26(4):717-728. doi: 10.1093/hmg/ddw403. Hum Mol Genet. 2017. PMID: 28062663 Free PMC article.
Revisiting olfactory receptors as putative drivers of cancer.
Ranzani M, Iyer V, Ibarra-Soria X, Del Castillo Velasco-Herrera M, Garnett M, Logan D, Adams DJ. Ranzani M, et al. Among authors: iyer v. Wellcome Open Res. 2017 Feb 10;2:9. doi: 10.12688/wellcomeopenres.10646.1. Wellcome Open Res. 2017. PMID: 28492065 Free PMC article.
Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries.
Metzakopian E, Strong A, Iyer V, Hodgkins A, Tzelepis K, Antunes L, Friedrich MJ, Kang Q, Davidson T, Lamberth J, Hoffmann C, Davis GD, Vassiliou GS, Skarnes WC, Bradley A. Metzakopian E, et al. Among authors: iyer v. Sci Rep. 2017 May 22;7(1):2244. doi: 10.1038/s41598-017-01766-5. Sci Rep. 2017. PMID: 28533524 Free PMC article.
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.
Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V, Kuijjer ML, Arends MJ, Brenn T, Harms PW, Wood GA, Adams DJ. Wong K, et al. Among authors: iyer v. Nat Commun. 2019 Jan 21;10(1):353. doi: 10.1038/s41467-018-08081-1. Nat Commun. 2019. PMID: 30664638 Free PMC article.
Collateral damage and CRISPR genome editing.
Thomas M, Burgio G, Adams DJ, Iyer V. Thomas M, et al. Among authors: iyer v. PLoS Genet. 2019 Mar 14;15(3):e1007994. doi: 10.1371/journal.pgen.1007994. eCollection 2019 Mar. PLoS Genet. 2019. PMID: 30870431 Free PMC article.
The mutational signature profile of known and suspected human carcinogens in mice.
Riva L, Pandiri AR, Li YR, Droop A, Hewinson J, Quail MA, Iyer V, Shepherd R, Herbert RA, Campbell PJ, Sills RC, Alexandrov LB, Balmain A, Adams DJ. Riva L, et al. Among authors: iyer v. Nat Genet. 2020 Nov;52(11):1189-1197. doi: 10.1038/s41588-020-0692-4. Epub 2020 Sep 28. Nat Genet. 2020. PMID: 32989322 Free PMC article.
1,134 results