Ito S - Search Results

1

A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.

Kuki N, Walmsley DL, Kanai K, Takechi S, Yoshida M, Murakami R, Takano K, Tominaga Y, Takahashi M, Ito S, Nakao N, Angove H, Baker LM, Carter E, Dokurno P, Le Strat L, Macias AT, Molyneaux CA, Murray JB, Surgenor AE, Hamada T, Hubbard RE. Kuki N, et al. Among authors: ito s. RSC Med Chem. 2023 Oct 19;14(12):2731-2737. doi: 10.1039/d3md00439b. eCollection 2023 Dec 13. RSC Med Chem. 2023. PMID: 38107172

2

Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.

Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N. Takano R, et al. Among authors: ito s. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815144 Free PMC article.

3

Discovery of a Novel Class of ERRα Agonists.

Shinozuka T, Ito S, Kimura T, Izumi M, Wakabayashi K. Shinozuka T, et al. Among authors: ito s. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821. doi: 10.1021/acsmedchemlett.1c00100. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055231 Free PMC article.

4

Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.

Fujita-Sato S, Ito S, Isobe T, Ohyama T, Wakabayashi K, Morishita K, Ando O, Isono F. Fujita-Sato S, et al. Among authors: ito s. J Biol Chem. 2011 Sep 9;286(36):31409-17. doi: 10.1074/jbc.M111.254003. Epub 2011 Jul 6. J Biol Chem. 2011. PMID: 21733845 Free PMC article.

5

Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.

Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T. Ito S, et al. J Biol Chem. 2002 Feb 22;277(8):6631-6. doi: 10.1074/jbc.M106525200. Epub 2001 Nov 30. J Biol Chem. 2002. PMID: 11733492 Free article.

6

Crystallization and preliminary x-ray studies of the Fab fragment from a humanized version of the mouse anti-human fas antibody HFE7a.

Ito S, Takayama T, Hanzawa H, Takahashi T, Miyadai K, Serizawa N, Haruyama H, Hata T. Ito S, et al. Protein Pept Lett. 2002 Jun;9(3):259-63. doi: 10.2174/0929866023408715. Protein Pept Lett. 2002. PMID: 12144523

7

Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab fragment.

Haruyama H, Ito S, Miyadai K, Takahashi T, Kawaida R, Takayama T, Hanzawa H, Hata T, Yamaguchi J, Yoshida-Kato H, Ichikawa K, Ohsumi J, Yonehara S, Serizawa N. Haruyama H, et al. Among authors: ito s. Biol Pharm Bull. 2002 Dec;25(12):1537-45. doi: 10.1248/bpb.25.1537. Biol Pharm Bull. 2002. PMID: 12499636 Free article.

8

Inhibiting RORγt/Th17 axis for autoimmune disorders.

Isono F, Fujita-Sato S, Ito S. Isono F, et al. Among authors: ito s. Drug Discov Today. 2014 Aug;19(8):1205-11. doi: 10.1016/j.drudis.2014.04.012. Epub 2014 Apr 30. Drug Discov Today. 2014. PMID: 24792721 Review.

9

Crystal structure of RANK ligand involved in bone metabolism.

Ito S, Hata T. Ito S, et al. Vitam Horm. 2004;67:19-33. doi: 10.1016/S0083-6729(04)67002-6. Vitam Horm. 2004. PMID: 15110169 Review.

10

Crystal structure of a 1beta-methylcarbapenem antibiotic, pivaloyloxymethyl (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[[(R)-5-oxopyrrolidin-3-yl]thio]-1-carbapen-2-em-3-carboxylate, CS-834 dihydrate.

Kobayashi K, Fukuhara H, Kawamoto I, Ito S, Hata T. Kobayashi K, et al. Among authors: ito s. Anal Sci. 2001 Feb;17(2):357-8. doi: 10.2116/analsci.17.357. Anal Sci. 2001. PMID: 11990557 Free article. No abstract available.

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