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Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas.
De Bacco F, Orzan F, Crisafulli G, Prelli M, Isella C, Casanova E, Albano R, Reato G, Erriquez J, D'Ambrosio A, Panero M, Dall'Aglio C, Casorzo L, Cominelli M, Pagani F, Melcarne A, Zeppa P, Altieri R, Morra I, Cassoni P, Garbossa D, Cassisa A, Bartolini A, Pellegatta S, Comoglio PM, Finocchiaro G, Poliani PL, Boccaccio C. De Bacco F, et al. Among authors: isella c. Cell Rep. 2023 Aug 29;42(8):112816. doi: 10.1016/j.celrep.2023.112816. Epub 2023 Jul 27. Cell Rep. 2023. PMID: 37505981 Free article.
TNF-α promotes invasive growth through the MET signaling pathway.
Bigatto V, De Bacco F, Casanova E, Reato G, Lanzetti L, Isella C, Sarotto I, Comoglio PM, Boccaccio C. Bigatto V, et al. Among authors: isella c. Mol Oncol. 2015 Feb;9(2):377-88. doi: 10.1016/j.molonc.2014.09.002. Epub 2014 Sep 26. Mol Oncol. 2015. PMID: 25306394 Free PMC article.
IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
Zanella ER, Galimi F, Sassi F, Migliardi G, Cottino F, Leto SM, Lupo B, Erriquez J, Isella C, Comoglio PM, Medico E, Tejpar S, Budinská E, Trusolino L, Bertotti A. Zanella ER, et al. Among authors: isella c. Sci Transl Med. 2015 Jan 28;7(272):272ra12. doi: 10.1126/scitranslmed.3010445. Sci Transl Med. 2015. PMID: 25632036 Free article.
A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.
Luraghi P, Bigatto V, Cipriano E, Reato G, Orzan F, Sassi F, De Bacco F, Isella C, Bellomo SE, Medico E, Comoglio PM, Bertotti A, Trusolino L, Boccaccio C. Luraghi P, et al. Among authors: isella c. Clin Cancer Res. 2018 Feb 15;24(4):807-820. doi: 10.1158/1078-0432.CCR-17-2151. Epub 2017 Oct 3. Clin Cancer Res. 2018. PMID: 28974546 Free article.
Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.
Corso S, Cargnelutti M, Durando S, Menegon S, Apicella M, Migliore C, Capeloa T, Ughetto S, Isella C, Medico E, Bertotti A, Sassi F, Sarotto I, Casorzo L, Pisacane A, Mangioni M, Sottile A, Degiuli M, Fumagalli U, Sgroi G, Molfino S, De Manzoni G, Rosati R, De Simone M, Marrelli D, Saragoni L, Rausei S, Pallabazzer G, Roviello F, Cassoni P, Sapino A, Bass A, Giordano S. Corso S, et al. Among authors: isella c. Neoplasia. 2018 May;20(5):443-455. doi: 10.1016/j.neo.2018.02.003. Epub 2018 Mar 23. Neoplasia. 2018. PMID: 29574251 Free PMC article.
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.
Apicella M, Giannoni E, Fiore S, Ferrari KJ, Fernández-Pérez D, Isella C, Granchi C, Minutolo F, Sottile A, Comoglio PM, Medico E, Pietrantonio F, Volante M, Pasini D, Chiarugi P, Giordano S, Corso S. Apicella M, et al. Among authors: isella c. Cell Metab. 2018 Dec 4;28(6):848-865.e6. doi: 10.1016/j.cmet.2018.08.006. Epub 2018 Aug 30. Cell Metab. 2018. PMID: 30174307 Free article.
A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.
Corti G, Bartolini A, Crisafulli G, Novara L, Rospo G, Montone M, Negrino C, Mussolin B, Buscarino M, Isella C, Barault L, Siravegna G, Siena S, Marsoni S, Di Nicolantonio F, Medico E, Bardelli A. Corti G, et al. Among authors: isella c. Clin Colorectal Cancer. 2019 Jun;18(2):91-101.e3. doi: 10.1016/j.clcc.2019.02.008. Epub 2019 Mar 7. Clin Colorectal Cancer. 2019. PMID: 30981604 Free article. Clinical Trial.
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes.
Orzan F, Pagani F, Cominelli M, Triggiani L, Calza S, De Bacco F, Medicina D, Balzarini P, Panciani PP, Liserre R, Buglione M, Fontanella MM, Medico E, Galli R, Isella C, Boccaccio C, Poliani PL; on behalf of the Neuro-Oncology group of Spedali Civili of Brescia. Orzan F, et al. Among authors: isella c. Lab Invest. 2020 Oct;100(10):1330-1344. doi: 10.1038/s41374-020-0437-0. Epub 2020 May 13. Lab Invest. 2020. PMID: 32404931 Free article.
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