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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey A, Kilanowski A, Sobczyk MK; 23andMe Research Team; Shringarpure SS, Mitchell R, Reis K, Reigo A; Estonian Biobank Research Team; Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-Navais P, Flatley C, Espuela-Ortiz A, Herrera-Luis E, Lominchar JVT, Bork-Jensen J, Marenholz I, Arnau-Soler A, Jeong A, Fawcett KA, Baurecht H, Rodriguez E, Alves AC, Kumar A, Sleiman PM, Chang X, Medina-Gomez C, Hu C, Xu CJ, Qi C, El-Heis S, Titcombe P, Antoun E, Fadista J, Wang CA, Thiering E, Wu B, Kress S, Kothalawala DM, Kadalayil L, Duan J, Zhang H, Hadebe S, Hoffmann T, Jorgenson E, Choquet H, Risch N, Njølstad P, Andreassen OA, Johansson S, Almqvist C, Gong T, Ullemar V, Karlsson R, Magnusson PKE, Szwajda A, Burchard EG, Thyssen JP, Hansen T, Kårhus LL, Dantoft TM, Jeanrenaud ACSN, Ghauri A, Arnold A, Homuth G, Lau S, Nöthen MM, Hübner N, Imboden M, Visconti A, Falchi M, Bataille V, Hysi P, Ballardini N, Boomsma DI, Hottenga JJ, Müller-Nurasyid M, Ahluwalia TS, Stokholm J, Chawes B, Schoos AM, Esplugues A, Bustamante M, Raby B, Arshad S, German C, Esko T, Milani LA, Metspalu A, Terao C, Abuabara K, Løset M, Hveem K, Jacobsson B, Pino-Yanes M, Strachan DP, Grarup N, Linneberg A,… See abstract for full author list ➔ Budu-Aggrey A, et al. Among authors: irvine ad. Nat Commun. 2023 Oct 4;14(1):6172. doi: 10.1038/s41467-023-41180-2. Nat Commun. 2023. PMID: 37794016 Free PMC article.
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
Weidinger S, Illig T, Baurecht H, Irvine AD, Rodriguez E, Diaz-Lacava A, Klopp N, Wagenpfeil S, Zhao Y, Liao H, Lee SP, Palmer CN, Jenneck C, Maintz L, Hagemann T, Behrendt H, Ring J, Nothen MM, McLean WH, Novak N. Weidinger S, et al. Among authors: irvine ad. J Allergy Clin Immunol. 2006 Jul;118(1):214-9. doi: 10.1016/j.jaci.2006.05.004. Epub 2006 Jun 9. J Allergy Clin Immunol. 2006. PMID: 16815158
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, Ruether A, Klopp N, Vogelberg C, Weiland SK, McLean WH, von Mutius E, Irvine AD, Kabesch M. Weidinger S, et al. Among authors: irvine ad. J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. doi: 10.1016/j.jaci.2008.02.014. Epub 2008 Apr 8. J Allergy Clin Immunol. 2008. PMID: 18396323
Atopic eczema and the filaggrin story.
Brown SJ, Irvine AD. Brown SJ, et al. Among authors: irvine ad. Semin Cutan Med Surg. 2008 Jun;27(2):128-37. doi: 10.1016/j.sder.2008.04.001. Semin Cutan Med Surg. 2008. PMID: 18620134 Review.
Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.
Bergboer JG, Zeeuwen PL, Irvine AD, Weidinger S, Giardina E, Novelli G, Den Heijer M, Rodriguez E, Illig T, Riveira-Munoz E, Campbell LE, Tyson J, Dannhauser EN, O'Regan GM, Galli E, Klopp N, Koppelman GH, Novak N, Estivill X, McLean WH, Postma DS, Armour JA, Schalkwijk J. Bergboer JG, et al. Among authors: irvine ad. J Invest Dermatol. 2010 Aug;130(8):2057-61. doi: 10.1038/jid.2010.88. Epub 2010 Apr 8. J Invest Dermatol. 2010. PMID: 20376060 Free article.
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2; Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC. Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, et al. Among authors: irvine ad. Nat Genet. 2010 Nov;42(11):985-90. doi: 10.1038/ng.694. Epub 2010 Oct 17. Nat Genet. 2010. PMID: 20953190 Free PMC article.
315 results