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Emerging airway smooth muscle targets to treat asthma.
Pulm Pharmacol Ther. 2013 Feb;26(1):132-44. doi: 10.1016/j.pupt.2012.08.008. Epub 2012 Sep 7.
Pulm Pharmacol Ther. 2013.
PMID: 22981423
Review.
Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension.
Wright DB, Tripathi S, Sikarwar A, Santosh KT, Perez-Zoghbi J, Ojo OO, Irechukwu N, Ward JP, Schaafsma D.
Wright DB, et al. Among authors: irechukwu n.
Pulm Pharmacol Ther. 2013 Feb;26(1):121-31. doi: 10.1016/j.pupt.2012.06.005. Epub 2012 Jun 27.
Pulm Pharmacol Ther. 2013.
PMID: 22750270
Review.
Item in Clipboard
Ca2+ handling and sensitivity in airway smooth muscle: emerging concepts for mechanistic understanding and therapeutic targeting.
Koopmans T, Anaparti V, Castro-Piedras I, Yarova P, Irechukwu N, Nelson C, Perez-Zoghbi J, Tan X, Ward JP, Wright DB.
Koopmans T, et al. Among authors: irechukwu n.
Pulm Pharmacol Ther. 2014 Dec;29(2):108-20. doi: 10.1016/j.pupt.2014.05.001. Epub 2014 May 14.
Pulm Pharmacol Ther. 2014.
PMID: 24831539
Review.
Item in Clipboard
Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle.
Shaifta Y, Irechukwu N, Prieto-Lloret J, MacKay CE, Marchon KA, Ward JP, Knock GA.
Shaifta Y, et al. Among authors: irechukwu n.
Br J Pharmacol. 2015 Nov;172(22):5265-80. doi: 10.1111/bph.13313. Epub 2015 Oct 23.
Br J Pharmacol. 2015.
PMID: 26294392
Free PMC article.
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Transforming growth factor-β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.
Shaifta Y, MacKay CE, Irechukwu N, O'Brien KA, Wright DB, Ward JPT, Knock GA.
Shaifta Y, et al. Among authors: irechukwu n.
J Physiol. 2018 Jan 1;596(1):47-66. doi: 10.1113/JP275033. Epub 2017 Nov 23.
J Physiol. 2018.
PMID: 29071730
Free PMC article.
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