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Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ.
Schellenbauer A, Guilly MN, Grall R, Le Bars R, Paget V, Kortulewski T, Sutcu H, Mathé C, Hullo M, Biard D, Leteurtre F, Barroca V, Corre Y, Irbah L, Rass E, Theze B, Bertrand P, Demmers JAA, Guirouilh-Barbat J, Lopez BS, Chevillard S, Delic J. Schellenbauer A, et al. Among authors: irbah l. Nucleic Acids Res. 2021 Nov 18;49(20):11728-11745. doi: 10.1093/nar/gkab980. Nucleic Acids Res. 2021. PMID: 34718776 Free PMC article.
Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage.
Etourneaud L, Moussa A, Rass E, Genet D, Willaume S, Chabance-Okumura C, Wanschoor P, Picotto J, Thézé B, Dépagne J, Veaute X, Dizet E, Busso D, Barascu A, Irbah L, Kortulewski T, Campalans A, Le Chalony C, Zinn-Justin S, Scully R, Pennarun G, Bertrand P. Etourneaud L, et al. Among authors: irbah l. Sci Adv. 2021 Aug 27;7(35):eabb3799. doi: 10.1126/sciadv.abb3799. Print 2021 Aug. Sci Adv. 2021. PMID: 34452908 Free PMC article.
Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing.
Gay D, Ghinatti G, Guerrero-Juarez CF, Ferrer RA, Ferri F, Lim CH, Murakami S, Gault N, Barroca V, Rombeau I, Mauffrey P, Irbah L, Treffeisen E, Franz S, Boissonnas A, Combadière C, Ito M, Plikus MV, Romeo PH. Gay D, et al. Among authors: irbah l. Sci Adv. 2020 Mar 20;6(12):eaay3704. doi: 10.1126/sciadv.aay3704. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32219160 Free PMC article.