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Molecular mechanism of fatty acid activation of FFAR1.
Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM. Kumari P, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2219569120. doi: 10.1073/pnas.2219569120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216523 Free PMC article.
Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.
Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Cahill TJ 3rd, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223524 Free PMC article.
Variable G protein determinants of GPCR coupling selectivity.
Okashah N, Wan Q, Ghosh S, Sandhu M, Inoue A, Vaidehi N, Lambert NA. Okashah N, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12054-12059. doi: 10.1073/pnas.1905993116. Epub 2019 May 29. Proc Natl Acad Sci U S A. 2019. PMID: 31142646 Free PMC article.
Agonist-induced formation of unproductive receptor-G12 complexes.
Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA. Okashah N, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21723-21730. doi: 10.1073/pnas.2003787117. Epub 2020 Aug 17. Proc Natl Acad Sci U S A. 2020. PMID: 32817560 Free PMC article.
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. Işbilir A, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29144-29154. doi: 10.1073/pnas.2013319117. Epub 2020 Nov 4. Proc Natl Acad Sci U S A. 2020. PMID: 33148803 Free PMC article.
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Maharana J, Ranjan A, Chaturvedi M, Jhingan GD, Laporte SA, Woodruff TM, Inoue A, Shukla AK. Pandey S, et al. Among authors: inoue a. Mol Cell. 2021 Nov 18;81(22):4605-4621.e11. doi: 10.1016/j.molcel.2021.09.007. Epub 2021 Sep 27. Mol Cell. 2021. PMID: 34582793 Free PMC article.
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S. El Khamlichi C, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2118847119. doi: 10.1073/pnas.2118847119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594393 Free PMC article.
2,542 results