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Page 1
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.
Coecke S, Ahr H, Blaauboer BJ, Bremer S, Casati S, Castell J, Combes R, Corvi R, Crespi CL, Cunningham ML, Elaut G, Eletti B, Freidig A, Gennari A, Ghersi-Egea JF, Guillouzo A, Hartung T, Hoet P, Ingelman-Sundberg M, Munn S, Janssens W, Ladstetter B, Leahy D, Long A, Meneguz A, Monshouwer M, Morath S, Nagelkerke F, Pelkonen O, Ponti J, Prieto P, Richert L, Sabbioni E, Schaack B, Steiling W, Testai E, Vericat JA, Worth A. Coecke S, et al. Altern Lab Anim. 2006 Feb;34(1):49-84. doi: 10.1177/026119290603400113. Altern Lab Anim. 2006. PMID: 16522150 No abstract available.
Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Björquist P, Carrondo MJ, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Küppers-Munther B, Müller-Vieira U, Noor F, Zeilinger K. Mandenius CF, et al. Altern Lab Anim. 2011 May;39(2):147-71. doi: 10.1177/026119291103900210. Altern Lab Anim. 2011. PMID: 21639679
Stem cell-derived systems in toxicology assessment.
Suter-Dick L, Alves PM, Blaauboer BJ, Bremm KD, Brito C, Coecke S, Flick B, Fowler P, Hescheler J, Ingelman-Sundberg M, Jennings P, Kelm JM, Manou I, Mistry P, Moretto A, Roth A, Stedman D, van de Water B, Beilmann M. Suter-Dick L, et al. Stem Cells Dev. 2015 Jun 1;24(11):1284-96. doi: 10.1089/scd.2014.0540. Epub 2015 Mar 31. Stem Cells Dev. 2015. PMID: 25675366 Review.
Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing.
Stacey GN, Coecke S, Price AB, Healy L, Jennings P, Wilmes A, Pinset C, Ingelman-Sundberg M, Louisse J, Haupt S, Kidd D, Robitski A, Jahnke HG, Lemaitre G, Myatt G. Stacey GN, et al. Adv Exp Med Biol. 2016;856:259-297. doi: 10.1007/978-3-319-33826-2_11. Adv Exp Med Biol. 2016. PMID: 27671727 Review.
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
Salonen JS, Nyman L, Boobis AR, Edwards RJ, Watts P, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF, Taavitsainen P, Pelkonen O. Salonen JS, et al. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093. Drug Metab Dispos. 2003. PMID: 12920164
An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.
Andersson TB, Sjöberg H, Hoffmann KJ, Boobis AR, Watts P, Edwards RJ, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Goldfarb PS, Lewis DF, Corcos L, Guillouzo A, Taavitsainen P, Pelkonen O. Andersson TB, et al. Drug Metab Dispos. 2001 May;29(5):712-20. Drug Metab Dispos. 2001. PMID: 11302938
541 results