Iimura S - Search Results

1

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.

Taniguchi T, Inagaki H, Baba D, Yasumatsu I, Toyota A, Kaneta Y, Kiga M, Iimura S, Odagiri T, Shibata Y, Ueda K, Seo M, Shimizu H, Imaoka T, Nakayama K. Taniguchi T, et al. Among authors: iimura s. ACS Med Chem Lett. 2019 Mar 15;10(5):737-742. doi: 10.1021/acsmedchemlett.8b00631. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31097992 Free PMC article.

2

Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

Shimizu H, Tanaka S, Toki T, Yasumatsu I, Akimoto T, Morishita K, Yamasaki T, Yasukochi T, Iimura S. Shimizu H, et al. Among authors: iimura s. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5113-8. doi: 10.1016/j.bmcl.2010.07.026. Epub 2010 Jul 13. Bioorg Med Chem Lett. 2010. PMID: 20675134

3

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

Shimizu H, Yasumatsu I, Hamada T, Yoneda Y, Yamasaki T, Tanaka S, Toki T, Yokoyama M, Morishita K, Iimura S. Shimizu H, et al. Among authors: iimura s. Bioorg Med Chem Lett. 2011 Feb 1;21(3):904-8. doi: 10.1016/j.bmcl.2010.12.078. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21232950

4

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

Shimizu H, Yamasaki T, Yoneda Y, Muro F, Hamada T, Yasukochi T, Tanaka S, Toki T, Yokoyama M, Morishita K, Iimura S. Shimizu H, et al. Among authors: iimura s. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4550-5. doi: 10.1016/j.bmcl.2011.05.115. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21705219

5

A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.

Matsui Y, Yasumatsu I, Yoshida KI, Iimura S, Ikeno Y, Nawano T, Fukano H, Ubukata O, Hanzawa H, Tanzawa F, Isoyama T. Matsui Y, et al. Among authors: iimura s. Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):156-160. doi: 10.1107/S2053230X18002108. Epub 2018 Feb 26. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29497019 Free PMC article.

6

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs.

Nakayama K, Terasawa H, Mitsui I, Ohsuki S, Uoto K, Iimura S, Soga T. Nakayama K, et al. Among authors: iimura s. Bioorg Med Chem Lett. 1998 Mar 3;8(5):427-32. doi: 10.1016/s0960-894x(98)00040-7. Bioorg Med Chem Lett. 1998. PMID: 9871592

7

A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.

Tanaka S, Toki T, Yokoyama M, Shimizu H, Yamasaki T, Yoneda Y, Muro F, Yasukochi T, Iimura S, Morishita K. Tanaka S, et al. Among authors: iimura s. Biol Pharm Bull. 2014;37(1):87-95. doi: 10.1248/bpb.b13-00628. Biol Pharm Bull. 2014. PMID: 24389485 Free article.

8

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.

Lapierre JM, Eathiraj S, Vensel D, Liu Y, Bull CO, Cornell-Kennon S, Iimura S, Kelleher EW, Kizer DE, Koerner S, Makhija S, Matsuda A, Moussa M, Namdev N, Savage RE, Szwaya J, Volckova E, Westlund N, Wu H, Schwartz B. Lapierre JM, et al. Among authors: iimura s. J Med Chem. 2016 Jul 14;59(13):6455-69. doi: 10.1021/acs.jmedchem.6b00619. Epub 2016 Jun 29. J Med Chem. 2016. PMID: 27305487

9

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.

Muro F, Iimura S, Yoneda Y, Chiba J, Watanabe T, Setoguchi M, Takayama G, Yokoyama M, Takashi T, Nakayama A, Machinaga N. Muro F, et al. Among authors: iimura s. Bioorg Med Chem. 2009 Feb 1;17(3):1232-43. doi: 10.1016/j.bmc.2008.12.026. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19124247

10

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.

Muro F, Iimura S, Sugimoto Y, Yoneda Y, Chiba J, Watanabe T, Setoguchi M, Iigou Y, Matsumoto K, Satoh A, Takayama G, Taira T, Yokoyama M, Takashi T, Nakayama A, Machinaga N. Muro F, et al. Among authors: iimura s. J Med Chem. 2009 Dec 24;52(24):7974-92. doi: 10.1021/jm901154c. J Med Chem. 2009. PMID: 19891440

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